Evaluation of Fatty Acid Contents and Biological Activities of Jurinea turcica

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dc.contributor.authorBahadir Semerci, Alican
dc.contributor.authorYildirim, Merve
dc.contributor.authorOztay, Fusun
dc.contributor.authorSagiroglu, Mehmet
dc.contributor.authorTunc, Kenan
dc.date.accessioned2024-02-23T11:26:16Z
dc.date.available2024-02-23T11:26:16Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractThe fatty acid profile, antioxidant/antibacterial, and cytotoxic effects of the extracts obtained from Jurinea turcica B.Do & gbreve;an& A.Duran have been evaluated for the first time in the current study. The fatty acid profile of ethanolic extracts was determined using the Soxhlet extractor by a gas chromatography-mass spectrometer. The antioxidant and antibacterial activities were measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferrous reduction tests and the disc diffusion technique. Additionally, the cytotoxicity and wound healing assays were performed on A549 cells. The highest amount of component in the leaf extract was docosanoic acid methyl ester, whereas abundant arachidonic acid methyl ester was mainly found in the flower extract. The IC50 values, the 50 % scavenging value for the DPPH radical, were 179.13 and 124.67 mu g/mL for the leaf and flower extracts, respectively. IC50 values (the half-maximal inhibitory concentration) were 10.4 and 24.7 mu g/mL for the flower and leaf extracts, respectively. The leaf extract showed more potent antibacterial activity on Enterococcus faecalis (17 mm) and Staphylococcus aureus (16 mm) bacteria than the flower extract. In conclusion, the extracts of J. turcica have anti-cancerogenic and antibacterial effects. Leaf extracts have antibacterial and anti-metastatic effects, while flower extracts show antioxidant, cytotoxic, and apoptotic properties in A549 cells.en_US
dc.identifier.doi10.1002/cbdv.202300084
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.pmid38010957en_US
dc.identifier.scopus2-s2.0-85178875509en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202300084
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10538
dc.identifier.wosWOS:001116950100001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial Activityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectCytotoxic Activityen_US
dc.subjectJurinea Turcicaen_US
dc.subjectFatty Acid Contenten_US
dc.titleEvaluation of Fatty Acid Contents and Biological Activities of Jurinea turcicaen_US
dc.typeArticleen_US

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