Melatonin prevents possible radiotherapy-induced thyroid injury

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dc.contributor.authorAricigil, Mitat
dc.contributor.authorDundar, Mehmet Akif
dc.contributor.authorYucel, Abitter
dc.contributor.authorEryilmaz, Mehmet Akif
dc.contributor.authorAktan, Meryem
dc.contributor.authorAlan, Mehmet Akif
dc.contributor.authorFindik, Sidika
dc.date.accessioned2024-02-23T14:20:19Z
dc.date.available2024-02-23T14:20:19Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractPurpose: We aimed to investigate the protective effect of melatonin in radiotherapy-induced thyroid gland injury in an experimental rat model.Materials and methods: Thirty-two rats were divided into four groups: the control group, melatonin treatment group, radiotherapy group and melatonin plus radiotherapy group. The neck region of each rat was defined by simulation and radiated with 2 Gray (Gy) per min with 6-MV photon beams, for a total dose of 18Gy. Melatonin was administered at a dose of 50mg/kg through intraperitoneal injection, 15min prior to radiation exposure. Thirty days after the beginning of the study, rats were decapitated and analyses of blood and thyroid tissue were performed.Results: Tumor necrosis factor- (TNF-), interleukin-1 beta (IL-1), thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) levels in the radiotherapy group were significantly higher than those in the melatonin plus radiotherapy group (p<.05), whereas interleukin-10 (IL-10) and glutathione (GSH) values were higher in the melatonin plus radiotherapy group (p<.05). The infiltration of inflammatory cells and percentage of apoptosis in the radiotherapy group were significantly higher than those in the melatonin plus radiotherapy group (p<.05).Conclusions: Melatonin helped protect thyroid gland structure against the undesired cytotoxic effects of radiotherapy in rats.en_US
dc.identifier.doi10.1080/09553002.2017.1397296
dc.identifier.endpage1356en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue12en_US
dc.identifier.pmid29095094en_US
dc.identifier.scopus2-s2.0-85034639415en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1350en_US
dc.identifier.urihttps://doi.org/10.1080/09553002.2017.1397296
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13118
dc.identifier.volume93en_US
dc.identifier.wosWOS:000418053900010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Radiation Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectThyroiden_US
dc.subjectRadiotherapyen_US
dc.subjectApoptosisen_US
dc.subjectInflammationen_US
dc.titleMelatonin prevents possible radiotherapy-induced thyroid injuryen_US
dc.typeArticleen_US

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