The exogenous application of naringenin and rosmarinic acid modulates functional traits in Lepidium sativum

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dc.contributor.authorSalehi, Hajar
dc.contributor.authorZhang, Leilei
dc.contributor.authorAlp-Turgut, Fatma Nur
dc.contributor.authorArikan, Busra
dc.contributor.authorElbasan, Fevzi
dc.contributor.authorOzfidan-Konakci, Ceyda
dc.contributor.authorBalci, Melike
dc.date.accessioned2024-02-23T12:20:14Z
dc.date.available2024-02-23T12:20:14Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: Phenolic modulators have attracted attention for their potential in shaping functional traits in plants. This work investigated the impact of naringenin (Nar) and rosmarinic acid (RA) on the functional properties of Lepidium sativum leaves and roots.Results: Untargeted metabolomics identified a diverse phenolic profile, including flavonoids, phenolic acids, low molecular weight phenolics, lignans, and stilbenes. Cluster, analysis of variance multiblock orthogonal partial least squares (AMOPLS), and orthogonal projection to latent structures discriminant analysis (OPLS-DA) multivariate analyses confirmed tissue-specific modulation of bioactive compounds. The tissue was the hierarchically most influential factor, explaining 27% of observed variability, while the treatment and their interaction were statistically insignificant. Thereafter, various in vitro assays were employed to assess antioxidant capacity, including 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2 '-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) radical scavenging activity, cupric ion reducing antioxidant capacity (CUPRAC), and ferric ion reducing antioxidant power (FRAP), metal chelating ability, and phosphomolybdenum (PMD) assays. Extracts were also tested for inhibitory effects on cholinesterase, amylase, glucosidase, and tyrosinase enzymes. RA application positively impacted antioxidant and enzyme inhibitory activities, holding valuable implications in shaping the health-promoting properties of L. sativum.Conclusion: The untargeted metabolomics analysis showed a significant tissue-dependent modulation of bioactive compounds, determining no synergistic effect between applying phenolic compounds in combination. Specifically, the sole application of RA increased anthocyanins and hydroxyphenyl propanoic acid content on leaves, which was strictly related to enhancing the biological activities.(c) 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.en_US
dc.identifier.doi10.1002/jsfa.13160
dc.identifier.issn0022-5142
dc.identifier.issn1097-0010
dc.identifier.pmid37994181en_US
dc.identifier.scopus2-s2.0-85178953455en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/jsfa.13160
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10597
dc.identifier.wosWOS:001118740200001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of The Science Of Food And Agricultureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhenolic Profilingen_US
dc.subjectElicitorsen_US
dc.subjectChemometricsen_US
dc.subjectFunctional Foodsen_US
dc.subjectNutraceuticalen_US
dc.subjectBioactive Constituentsen_US
dc.titleThe exogenous application of naringenin and rosmarinic acid modulates functional traits in Lepidium sativumen_US
dc.typeArticleen_US

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