Increased incidence of malignancy in patients with primary hyperparathyroidism

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dc.contributor.authorKarakose, Melia
dc.contributor.authorKocabas, Muhammet
dc.contributor.authorCan, Mustafa
dc.contributor.authorCaliskan Burgucu, Hatice
dc.contributor.authorCordan, Ilker
dc.contributor.authorKulaksizoglu, Mustafa
dc.contributor.authorKarakurt, Feridun
dc.date.accessioned2024-02-23T14:37:24Z
dc.date.available2024-02-23T14:37:24Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: Primary hyperparathyroidism (PHPT) is a disease that is diagnosed more frequently and generally in the asymptomatic period, with widely available biochemical tests. Evidence suggesting an association between PHPT and malignancy risk is increasing. Clarification of this association will be useful in PHPT for malignancy screening and management of patients with PHPT. In this study, we aimed to investigate the frequency of cancer in PHPT patients. Materials and methods: A total of 775 PHPT patients were included in the retrospective study. Demographic, clinical and laboratory data of the patients were evaluated retrospectively. Results: Malignancy was detected in 128 (16.50%) of 775 PHPT patients (female/male: 625/150). The mean age at diagnosis of PHPT was 57.99 +/- 10.86 years, and the mean age at diagnosis of malignancy was 57.46 +/- 11.17 years. Of the 128 patients with malignancy, 53 (41.40%) were diagnosed in the same year as PHPT. In terms of malignancy types, 51 (6.50%) of 775 PHPT patients had thyroid cancer. Thyroid cancer was followed by breast cancer (2.30%) and stomach cancer (1%) in order of frequency. Conclusion: We think that PHPT patients should be examined more carefully in terms of cancer risk, especially thyroid cancer. More comprehensive studies are needed to clarify the relationship between PHPT and cancer.en_US
dc.identifier.doi10.3906/sag-2012-18
dc.identifier.endpage2028en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid33957725en_US
dc.identifier.scopus2-s2.0-85114254034en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2023en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2012-18
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16094
dc.identifier.volume51en_US
dc.identifier.wosWOS:000691544700055en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPrimary Hyperparathyroidismen_US
dc.subjectCanceren_US
dc.subjectThyroid Canceren_US
dc.titleIncreased incidence of malignancy in patients with primary hyperparathyroidismen_US
dc.typeArticleen_US

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