Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder

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dc.contributor.authorBilgic, Ayhan
dc.contributor.authorAbusoglu, Sedat
dc.contributor.authorSadic celikkol, Cagla
dc.contributor.authorOflaz, Mehmet Burhan
dc.contributor.authorAkca, Omer Faruk
dc.contributor.authorSivrikaya, Abdullah
dc.contributor.authorBaysal, Tamer
dc.date.accessioned2024-02-23T14:17:11Z
dc.date.available2024-02-23T14:17:11Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractAim There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD. Materials and Methods A total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system. Results Serum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower. Conclusions These findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Necmettin Erbakan University [181218002]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Coordination Unit of Necmettin Erbakan University under Grant [number 181218002].en_US
dc.identifier.doi10.1080/00207454.2020.1841187
dc.identifier.endpage834en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.issue8en_US
dc.identifier.pmid33086922en_US
dc.identifier.scopus2-s2.0-85094907624en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage826en_US
dc.identifier.urihttps://doi.org/10.1080/00207454.2020.1841187
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12973
dc.identifier.volume132en_US
dc.identifier.wosWOS:000586071700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutism Spectrum Disorderen_US
dc.subjectTryptophanen_US
dc.subjectKynurenineen_US
dc.subjectToddlersen_US
dc.subjectPreschool Childrenen_US
dc.titleAltered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorderen_US
dc.typeArticleen_US

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