Is there any association between antidepressants and restless legs syndrome in a large Turkish population receiving mono or combined treatment? A cross-sectional comparative study

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dc.contributor.authorOdabas, Faruk Omer
dc.contributor.authorUca, Ali Ulvi
dc.date.accessioned2024-02-23T14:20:45Z
dc.date.available2024-02-23T14:20:45Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE: Here, we aimed at investigating whether the treatment with antidepressants is associated with restless legs syndrome (RLS) and at determining the effects of mono or combined antidepressant therapy on the patients with RLS. METHODS: Five hundred and fifty-five patients with RLS receiving mono or combined antidepressant therapy were included in the study group, and 555 individuals with no history of the use of antidepressants constituted the control group. The diagnosis of restless leg syndrome was performed using a questionnaire under the criteria formed by the International Restless Leg Syndrome Study Group. RESULTS: Both the patients treated with antidepressants in the study group and those in the control group had similar demographic characteristics. The prevalence of RLS was detected as 9.2% (n = 51) in the study group treated with antidepressants and as 5.9% (n = 33) in the controls. The difference was statistically significant at borderline (rho = 0.053). While restless leg syndrome was diagnosed merely in 9 (6.8%) of 133 patients receiving combined treatment, 42 (10%) of 422 patients receiving monotherapy were diagnosed with RLS, and the difference was not statistically significant (rho = 0.306). The frequency of developing restless leg syndrome was found to be significant only in the use of escitalopram (rho = 0.023), whereas it was found to have a tendency to significant in the use of duloxetine (rho = 0.060). Among other participants receiving mono or combined treatment, no significant difference was observed. CONCLUSIONS: The occurrence of RLS can be seen as an adverse effect in the patients receiving mono or combined antidepressant treatment; however, the frequency of restless leg syndrome among those treated with antidepressants is similar to that seen in general population.en_US
dc.identifier.doi10.1080/24750573.2018.1480855
dc.identifier.endpage569en_US
dc.identifier.issn2475-0573
dc.identifier.issn2475-0581
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85052083887en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage565en_US
dc.identifier.urihttps://doi.org/10.1080/24750573.2018.1480855
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13294
dc.identifier.volume29en_US
dc.identifier.wosWOS:000510621700015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPsychiatry And Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntidepressant Treatmenten_US
dc.subjectCombined Therapyen_US
dc.subjectMonotherapyen_US
dc.subjectRestless Legs Syndromeen_US
dc.titleIs there any association between antidepressants and restless legs syndrome in a large Turkish population receiving mono or combined treatment? A cross-sectional comparative studyen_US
dc.typeArticleen_US

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