Effects of zinc supplementation on metallothionein levels in ischemic renal tissue

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dc.contributor.authorYazgan, Betul
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorAvunduk, Mustafa Cihat
dc.date.accessioned2024-02-23T14:20:28Z
dc.date.available2024-02-23T14:20:28Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractWe investigated how zinc (Zn) supplementation affects metallothionein levels in the cortex and medulla of ischemic renal tissue of rats. We used adult male rats divided into four groups: group 1, untreated control; group 2, sham-operated; group 3, ischemia-reperfusion; group 4, ischemia-reperfusion + 5 g/kg Zn. Renal tissue was analyzed using immunostaining of rat metallothionein. Cells stained with metallothionein were counted and their percentage was calculated. We found that the Zn supplemented ischemia and reperfusion group exhibited a greater percentage of cells stained strongly for metallothionein in the renal cortex than all other groups. In the renal medulla, percentages of weak staining for metallothionein in the control and ischemia and reperfusion groups were greater than those in the sham and Zn-supplemented ischemia/reperfusion groups. Our findings indicate that the main effect of Zn in the renal tissue occurs in the cortex, while metallothionein synthesis in the renal medulla is unaffected.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University [13102019]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK; project no. 13102019).en_US
dc.identifier.doi10.1080/10520295.2019.1691264
dc.identifier.endpage296en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid31984797en_US
dc.identifier.scopus2-s2.0-85078415761en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage285en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1691264
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13164
dc.identifier.volume95en_US
dc.identifier.wosWOS:000509447700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemiaen_US
dc.subjectKidneyen_US
dc.subjectMetallothioneinen_US
dc.subjectRaten_US
dc.subjectRenal Tissueen_US
dc.subjectReperfusionen_US
dc.subjectSupplementationen_US
dc.subjectZincen_US
dc.titleEffects of zinc supplementation on metallothionein levels in ischemic renal tissueen_US
dc.typeArticleen_US

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