Prevention of Retrosternal Pericardial Adhesions After Cardiac Surgery With Mitomycin C

Basit Öğe Kaydı
dc.contributor.authorOrhan, Atilla
dc.contributor.authorGormus, Niyazi
dc.contributor.authorToy, Hatice
dc.contributor.authorGormus, Isik Solak
dc.contributor.authorCaglayan, Osman
dc.contributor.authorTanyeli, Omer
dc.date.accessioned2024-02-23T14:03:02Z
dc.date.available2024-02-23T14:03:02Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBackground Cross Mark Retrosternal pericardial adhesions may cause significant injuries to the heart and great vessels in cases that require reoperation. Fibroblast proliferation is one of the mechanisms for adhesion formation. Inhibition of fibroblast proliferation is important in reduction of retrosternal adhesions. Mitomycin C (MMC) is able to reduce fibroblast proliferation. We aimed to determine the effect of MMC on prevention of retrosternal pericardial adhesions after primary cardiac operations. Methods Thirty Sprague-Dawley female rats were used in the study. The rats were divided into two groups. First group was control (n = 10) and second group was MMC study group (n = 20). Xiphoid cartilage resection and retrosternal abrasion via subxiphoidal incision was performed. In the study group, MMC (1 mg/kg) was topically applied to the retrosternal space. After 15 days, rats were taken into reoperation and adhesion was graded. Tissue and blood samples were taken before termination procedure. Standard staining procedures and fibroblast growth factor receptor 3 antibody staining, were applied immunohistochemically to tissue samples. Results The average adhesion scores of the control (n = 10) and study (n = 20) (MMC; 1 mg/kg) groups were 2.50 +/- 1.27 and 0.70 +/- 0.86, respectively. The adhesion score of the study group was lower than the control group (p < 0.05). Immunohistochemical samples revealed that tissue fibroblast intensity was significantly higher in the control group than the study group (p < 0.05). There was no statistical significance between two groups in case of hydroxyproline levels (p > 0.05). Conclusion MMC was found to be effective in the prevention of retrosternal pericardial adhesions without any delay in normal tissue regeneration.en_US
dc.description.sponsorshipScientific Research Projects Coordinator's Office of our university [1007/0710]en_US
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Coordinator's Office of our university (Project No: 1007/0710).en_US
dc.identifier.doi10.1016/j.hlc.2013.10.080
dc.identifier.endpage362en_US
dc.identifier.issn1443-9506
dc.identifier.issn1444-2892
dc.identifier.issue4en_US
dc.identifier.pmid24252449en_US
dc.identifier.scopus2-s2.0-84897034666en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://doi.org/10.1016/j.hlc.2013.10.080
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11945
dc.identifier.volume23en_US
dc.identifier.wosWOS:000334820200012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofHeart Lung And Circulationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMitomycin Cen_US
dc.subjectPericardial Adhesionsen_US
dc.subjectCardiac Reoperationsen_US
dc.subjectSurgical Adhesionsen_US
dc.subjectAdhesion Preventionen_US
dc.titlePrevention of Retrosternal Pericardial Adhesions After Cardiac Surgery With Mitomycin Cen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu