Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: A prospective, crossover study

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dc.contributor.authorSolak, Yalcin
dc.contributor.authorBiyik, Zeynep
dc.contributor.authorAtalay, Huseyin
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorGuney, Figen
dc.contributor.authorTurk, Suleyman
dc.contributor.authorCovic, Adrian
dc.date.accessioned2024-02-23T14:24:18Z
dc.date.available2024-02-23T14:24:18Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractAim: Pruritus is common in dialysis patients. Peripheral neuropathy is also prevalent in this patient population. However, the role of neuropathy in the genesis of uraemic itch has not been adequately studied to date. Therefore, we aimed to investigate the effects of gabapentin and pregabalin on uraemic pruritus along with neuropathic pain in patients receiving haemodialysis. Methods: This is a 14 week long randomized, prospective, cross-over trial. Haemodialysis patients with established neuropathy and/or neuropathic pain were included. Fifty patients were randomly assigned to gabapentin 300 mg after each haemodialysis session and pregabalin 75 mg daily. After 6 weeks of treatment, cross-over was performed and patients received the other drug for another 6 weeks. Short Form of McGill Pain Questionnaire and Visual Analogue Scale were used to evaluate pain and pruritus, respectively. At each week's visit, patients were interrogated in terms of adverse effects of study drugs. Baseline laboratory data and demographic characteristics were recorded from patient charts. Results: Forty (12 males, 28 females) out of 50 patients completed the study. Mean age was 58.2 +/- 13.7. Overall, 29 out of 40 patients (72.5%) had pruritus symptoms at baseline evaluation. Fifteen patients (37.5%) were diabetic. Thirty-one out of 40 patients (77.5%) had electromyography (EMG)-proven peripheral neuropathy. Twenty three patients (57.5%) had both EMG-proven neuropathy and pruritus. Gabapentin and pregabalin improved both neuropathic pain and pruritus significantly. There was no difference between the study drugs in terms of efficacy against pain and pruritus. Conclusion: Treatment of neuropathic pain with either pregabalin or gabapentin effectively ameliorates uraemic itch.en_US
dc.description.sponsorshipERA-EDTA fellowship programen_US
dc.description.sponsorshipDr. A. Gaipov received grant support from the ERA-EDTA fellowship program. No sources of funding were used to conduct this study or prepare this manuscript.en_US
dc.identifier.doi10.1111/j.1440-1797.2012.01655.x
dc.identifier.endpage717en_US
dc.identifier.issn1320-5358
dc.identifier.issn1440-1797
dc.identifier.issue8en_US
dc.identifier.pmid22909343en_US
dc.identifier.scopus2-s2.0-84868160098en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage710en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1797.2012.01655.x
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13895
dc.identifier.volume17en_US
dc.identifier.wosWOS:000310550200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofNephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGabapentinen_US
dc.subjectHaemodialysisen_US
dc.subjectItchen_US
dc.subjectPeripheral Neuropathyen_US
dc.subjectPregabalinen_US
dc.subjectPruritusen_US
dc.titlePregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: A prospective, crossover studyen_US
dc.typeArticleen_US

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