Association between ischemia-modified albumin, homocysteine, vitamin B12 and folic acid in patients with severe sepsis

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dc.contributor.authorErdem, Said Sami
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorCicekler, Humeyra
dc.contributor.authorGul, Mehmet
dc.date.accessioned2024-02-23T14:29:45Z
dc.date.available2024-02-23T14:29:45Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractBackground: The aim of the present study was to investigate scrum ischemia-modified albumin (IMA), homocysteine, malondialdehyde (MDA), vitamin B-12 and folic acid levels in patients with severe sepsis, compared to healthy control subjects. Also, we examined associations of these parameters with high-sensitivity C-reactive protein (hsCRP) in patients with severe sepsis and healthy control subjects. Methods: This study was performed on 71 (40 male, 31 female) patients with severe sepsis aged 18-65 years and 70 (34 male, 36 female) healthy control subjects aged 18-65 years. Samples of patients were obtained at study entry within 24 h of onset of severe sepsis. Results: Serum IMA, homocysteine and MDA levels of the patients with severe sepsis were significantly higher than those of the healthy control subjects (p<0.0 I for IMA and homocysteine, and p<0.001 for MDA). There was no significant difference between serum vitamin B12 and folic acid levels of the groups. Serum hsCRP levels were positively correlated with IMA (p<0.01) and MDA (p<0.01) in the patients with severe sepsis. Conclusions: Our findings show that IMA may be useful as a prognostic biomarker because it can indicate the severity of illness in patients with sepsis.en_US
dc.identifier.doi10.1515/cclm-2011-0794
dc.identifier.endpage1421en_US
dc.identifier.issn1434-6621
dc.identifier.issn1437-4331
dc.identifier.issue8en_US
dc.identifier.pmid22868807en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1417en_US
dc.identifier.urihttps://doi.org/10.1515/cclm-2011-0794
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14848
dc.identifier.volume50en_US
dc.identifier.wosWOS:000309200500019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofClinical Chemistry And Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFolic Aciden_US
dc.subjectHomocysteineen_US
dc.subjectIschemia-Modified Albuminen_US
dc.subjectSepsisen_US
dc.subjectVitamin B-12en_US
dc.titleAssociation between ischemia-modified albumin, homocysteine, vitamin B12 and folic acid in patients with severe sepsisen_US
dc.typeArticleen_US

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