Oxidative Stress-Related miRNAs in Patients with Severe Acne Vulgaris

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dc.contributor.authorCalis, Betul
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorAtaseven, Arzu
dc.contributor.authorTemiz, Selami Aykut
dc.contributor.authorOnmaz, Duygu Eryavuz
dc.date.accessioned2024-02-23T14:37:47Z
dc.date.available2024-02-23T14:37:47Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground: Acne vulgaris is a common chronic inflammatory skin disease in adolescents and oxidative stress plays an important role in acne pathology. However, the pathology of acne has not yet been fully elucidated. miRNAs are small noncoding RNAs, and there is increasing evidence for their role in the pathogenesis of skin diseases such as psoriasis, atopic dermatitis, and other inflammatory diseases. Aims and Objectives: The aim of the study was to investigate serum malondialdehyde (MDA) and glutathione (GSH) levels with plasma miRNA expression profile related with oxidative stress in patients with severe acne vulgaris. Materials and Methods: Fifty seven female patients with severe acne and 40 healthy women were included in the study. Plasma miRNA-31, miRNA-200a, and miRNA-21 levels were evaluated by using real-time quantitative polymerase chain rection analysis. MDA and GSH levels were measured as per the manufacturer's procedures using commercial ELISA kits. Results: Plasma miRNA-21 levels were statistically significantly higher in patients with severe acne compared to the control group (P =0.003). Plasma miRNA-200a (P =0.303) and miRNA-31 (P =.652) levels were slightly higher in patients with severe acne compared to the control group, but this difference was not statistically significant. Serum MDA levels (P =.047) were higher in patients with severe acne compared to control group, while serum GSH levels (P =.001) were lower. Conclusion: These results show that oxidative damage is involved in acne etiopathogenesis and especially miRNA-21 may have an important role in the pathogenesis of acne vulgaris.en_US
dc.description.sponsorshipNecmettin Erbakan University [181318003]en_US
dc.description.sponsorshipThis work was supported by the Necmettin Erbakan University Scientific Research Projects Coordinator (grant numbers: Proje no: 181318003).en_US
dc.identifier.doi10.4103/ijd.ijd_467_22
dc.identifier.endpage661en_US
dc.identifier.issn0019-5154
dc.identifier.issn1998-3611
dc.identifier.issue6en_US
dc.identifier.pmid36998860en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage657en_US
dc.identifier.urihttps://doi.org/10.4103/ijd.ijd_467_22
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16242
dc.identifier.volume67en_US
dc.identifier.wosWOS:001094795500005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcne Vulgarisen_US
dc.subjectGlutathioneen_US
dc.subjectMirnaen_US
dc.subjectMalondialdehydeen_US
dc.subjectOxidative Stressen_US
dc.titleOxidative Stress-Related miRNAs in Patients with Severe Acne Vulgarisen_US
dc.typeArticleen_US

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