Thyroid Nodules in Patients with Acromegaly: Frequency According to the ACR TI-RADS Classification and its Relationship with Disease Activity

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dc.contributor.authorCan, Mustafa
dc.contributor.authorKocabas, Muhammet
dc.contributor.authorKarakose, Melia
dc.contributor.authorBurgucu, Hatice Caliskan
dc.contributor.authorYarar, Zeliha
dc.contributor.authorKulaksizoglu, Mustafa
dc.contributor.authorKarakurt, Feridun
dc.date.accessioned2024-02-23T14:16:50Z
dc.date.available2024-02-23T14:16:50Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractPurpose: In our study, we aimed to determine the frequency of thyroid nodules in patients with acromegaly according to the American College of Radiology (ACR) Thyroid Imaging, Reporting and Data System (TI-RADS) classification and its relationship with acromegaly disease activity. Methods: A total of 56 patients with acromegaly and age, sex, and body mass index matched with 56 healthy control subjects were included in our study. Thyroid-stimulating hormone, free thyroxine, and anti-thyroperoxidase antibody levels of patients and control subjects were measured. In addition, patients and healthy controls were evaluated by ultrasonography to determine thyroid structure, thyroid volume, and thyroid nodules and to make ACR TI-RADS classification. Results: Thyroid nodules were present in 31 (55.4%) of 56 patients in the acromegaly group and 20 (35.7%) of 56 subjects in the control group, and the frequency of thyroid nodules was significantly higher in the acromegaly group (p=0.038). The mean number of nodules in the acromegaly group and control group was 1.271.43 and 0.48 +/- 0.73, respectively, and the mean number of nodules was significantly higher in the acromegaly group (p=0.003). The number of patients with TI-RADS 1, TI-RADS 2, and TI-RADS 4 nodules in the acromegaly group was higher than the control group (p=0.026, p=0.049, p=0.007, respectively). No difference was found in terms of cytological findings between those who have undergone FNAB in the acromegaly group and control group. Conclusion: In our study, we found that the frequency of thyroid nodules, the number of thyroid nodules, and the number of TI-RADS 1, TI-RADS 2, and TI-RADS 4 nodules increased in patients with acromegaly. There was no significant difference between acromegaly disease activity and thyroid nodule frequency, number of thyroid nodules, and TI-RADS classifications.en_US
dc.identifier.doi10.1055/a-1500-4591
dc.identifier.endpage936en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue12en_US
dc.identifier.pmid34425596en_US
dc.identifier.scopus2-s2.0-85113774519en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage931en_US
dc.identifier.urihttps://doi.org/10.1055/a-1500-4591
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12825
dc.identifier.volume129en_US
dc.identifier.wosWOS:000688469600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofExperimental And Clinical Endocrinology & Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcromegalyen_US
dc.subjectAcr Ti-Radsen_US
dc.subjectThyroid Noduleen_US
dc.subjectDisease Activityen_US
dc.titleThyroid Nodules in Patients with Acromegaly: Frequency According to the ACR TI-RADS Classification and its Relationship with Disease Activityen_US
dc.typeArticleen_US

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