Fibrinogen-A? THR312ALA Polymorphism is Associated to Chronic Thromboembolic Pulmonary Hypertension in Turkey

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dc.contributor.authorCortuk, Mustafa
dc.contributor.authorYildizeli, Bedrettin
dc.contributor.authorKurar, Ercan
dc.contributor.authorKayis, Seyit Ali
dc.contributor.authorTanriverdi, Elif
dc.contributor.authorCetinkaya, Erdogan
dc.date.accessioned2024-02-23T14:29:36Z
dc.date.available2024-02-23T14:29:36Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackground: Chronic thromboembolic pulmonary hypertension is a condition that occurs after mechanical obstruction of the pulmonary arteries by thrombus. Since the frequency and demographics of chronic thromboembolic pulmonary hypertension differ between countries, it is thought that genetic factors may play a role in its development. The aim of this study is to reveal the status of VKORC1, CYP2C9*3, CYP2C9*7, and fibrinogen-A alpha THR312ALA gene polymorphisms in chronic thromboembolic pulmonary hypertension patients in Turkey.Methods: In this prospective cross-sectional study, a total of 46 chronic thromboembolic pulmonary hypertension patients and 106 healthy volunteers were included. Polymerase chain reaction-restriction fragment length polymorphism method was used to determine candidate gene polymorphisms for chronic thromboembolic pulmonary hypertension. The general population parameters of each locus were calculated, and the relationship between dominant, co-dominant, and recessive genotype models and chronic thrombo-embolic pulmonary hypertension was analyzed.Results: For the fibrinogen-A alpha gene, those with the THR/THR genotype were found to have a 13.51 (95% CI: 2.688-33.333) times less susceptibility rate to the disease than those with the ALA/ THR genotype, the susceptibility of THR/ALA genotype to the disease was 5.026 (95% CI: 1.774-14.242) times more than those with ALA/ALA genotype. There was no difference between patient groups for VKORC1, CYP2C9*3 genes (P > .05). Since the CYP2C9*7 patient group was monomorphic for the ILE allele, the patient/control odds ratio and 95% CI could not be calculated.Conclusion: This study shows that there is an association between the fibrinogen-A alpha gene ALA polymorphism at the amino acid position of 312 and the development of chronic thromboembolic pulmonary hypertension, but not between the CYP2C9 and VKORC1 gene polymorphisms.en_US
dc.description.sponsorshipKarabuek University, Coordinatorship of Research Project [KB?BAP-17-KP-073]en_US
dc.description.sponsorshipThis study was supported by Karabuek University, Coordinatorship of Research Projects (KBUEBAP-17-KP-073).en_US
dc.identifier.doi10.14744/AnatolJCardiol.2022.2392
dc.identifier.endpage159en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue3en_US
dc.identifier.pmid36856592en_US
dc.identifier.scopus2-s2.0-85149427201en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2022.2392
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14763
dc.identifier.volume27en_US
dc.identifier.wosWOS:000954450700007en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofAnatolian Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Thromboembolic Pulmonary Hypertensionen_US
dc.subjectPulmonary Arterial Hyper-Tensionen_US
dc.subjectAnticoagulantsen_US
dc.subjectGenetic Polymorphismen_US
dc.subjectFibrinogen Alphaen_US
dc.subjectRflpen_US
dc.titleFibrinogen-A? THR312ALA Polymorphism is Associated to Chronic Thromboembolic Pulmonary Hypertension in Turkeyen_US
dc.typeArticleen_US

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