Eser elementlerin obezite ve framingham risk skoru üzerine etkisinin incelenmesi
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Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Obezite ve fazla kilo baĢta kardiyovasküler ve endokrinolojik olmak üzere pek çok
hastalığa yatkınlık oluĢturmaktadır. Bu çalıĢmanın amacı, obez olan ve olmayan bireylerde
serum eser element [bakır(Cu), çinko(Zn), demir(Fe) ve selenyum(Se)] düzeylerini tespit
etmek ve bu bireylerdeki Framingham risk skorunu belirleyerek eser elementler ile arasındaki
iliĢkiyi incelemektir.
Gereç ve yöntem: Kesitsel tipte planlanan bu araĢtırmanın evrenini Necmettin Erbakan
Üniversitesi Meram Tıp Fakültesi Aile Hekimliği Polikliniği’ne 01.03.2022-31.04.2022
tarihleri arasında baĢvuran bireyler oluĢturdu. Katılımcılar beden kitle indeksi (BKĠ)
değerlerine göre 3 ayrı gruba ayrıldı. Gruplar arasında yaĢ dağılımı, kadın ve erkek birey
sayısı ve sigara içen-içmeyen birey sayıları benzer tutulmaya çalıĢıldı. Bireylerin
sosyodemografik özellikleri, beden kitle indeksleri, sistolik ve diyastolik kan basıçları,
hemogram, lipit paneli parametreleri, Framingham risk skoru değerleri kaydedildi.
Katılımcıların serum demir, çinko, bakır ve selenyum düzeyleri Necmettin Erbakan
Üniversitesi Tıbbi Biyokimya Anabilim Dalı laboratuvarında spektrofotometri yöntemiyle
analiz edildi. Veriler Statistical Package for the Social Sciences (SPSS) versiyon 22.0
istatistik paket programında değerlendirildi. Ġstatistiksel anlamlılık p<0.05 olarak kabul edildi.
Bulgular: ÇalıĢmaya toplam 180 kiĢi dahil edildi ve bireylerin %50,0’ı erkek (n=90) idi.
Katılımcıların Framingham Risk Skoru (FRS) ortalamaları 9,31±7,99 (1-37), bel çevresi
ortalaması 95,63±15,08 (61-132) cm ve BKĠ ortalaması 27,58±5,70 (18-60,55) kg/m2 idi.
Bireylerin %33,9’u (n=61) normal kilolu, %33,3’ü (n=60) fazla kilolu ve %32,8’i (n=59) obez
idi. Normal kilolu bireylerin yaĢ ortalamaları (41,39±9,12), obez bireylerden (45,69±7,60)
daha düĢüktü (p=0,016). Normal kilolu bireylerin ortalama FRS’leri(7,84±3,05) fazla kilolu
(8,80±3,39) ve obez (13,39±6,24) grubun ortalama FRS değerlerinden daha düĢük saptandı
v
(p<0,001). DüĢük FRS değerine sahip bireylerin bel çevresi (p<0,001) daha düĢüktü. Serum
bakır düzeyleri ve BKĠ arasında pozitif yönde zayıf korelasyon saptandı (r=0,176 p=0,018).
Ölçülen diğer eser element düzeylerinin BKĠ ve FRS ile olan iliĢkileri incelendiğinde anlamlı
bir iliĢki saptanmadı.
Sonuç: Normal kilolu bireylerde kardiyovasküler risk düzeyinin daha düĢük olduğu tespit
edildi. Ayrıca bireylerin serum bakır düzeyleri ile BKĠ değerleri arasında pozitif yönlü iliĢki
olduğu saptandı. Serum Se, Zn ve Fe değerlerinin BKĠ ve FRS değeri ile iliĢkisi olmadığı
görüldü. Dolayısıyla serum eser element düzeyi tayininin obezite ve kardiyovasküler hastalık
tanı ve takibinde klinik pratiğe girmesi için halen randomize kontrollü çalıĢmalara ihtiyaç
vardır.
Obesity and excess weight predispose to many diseases, especially cardiovascular and endocrinological. Prediction of obesity and its complications is important in diagnosis and treatment. The aim of this study is to determine the serum trace element [copper(Cu), zinc(Zn), iron(Fe) and selenium(Se)] levels in obese and non-obese individuals and to examine the relationship between trace elements by determining the Framingham risk score in these individuals. Materials and methods: The population of this cross-sectional study consisted of individuals who applied to Necmettin Erbakan University Meram Medical Faculty Family Medicine Polyclinic between 01.03.2022 and 31.04.2022. Participants were divided into 3 groups according to their body mass index (BMI) values. Age distribution, the number of male and female individuals, and the number of smokers and non-smokers were tried to be kept similar between the groups. Sociodemographic characteristics, body mass indexes, systolic and diastolic blood pressures, hemogram, lipid panel parameters, Framingham risk score values of the individuals were recorded. The serum iron, zinc, copper and selenium levels of the participants were analyzed by spectrophotometry method in the laboratory of Necmettin Erbakan University Medical Biochemistry Department. The data were evaluated in the Statistical Package for the Social Sciences (SPSS) version 22.0 statistical package program. Statistical significance was accepted as p<0.05. Results: A total of 180 people were included in the study and 50.0% of the individuals were male (n=90). The mean Framingham Risk Score (FRS) of the participants was 9.31±7.99 (1- 37), the mean waist circumference was 95.63±15.08 (61-132) cm, and the mean BMI was 27.58±5.70 (18- 60.55) kg/m2. 33.9% (n=61) of the individuals were normal weight, 33.3% (n=60) were overweight and 32.8% (n=59) were obese. The mean age of normal-weight vii individuals (41.39±9.12) was lower than that of obese individuals (45.69±7.60) (p=0.016). The mean FRS of normal weight individuals (7.84±3.05) was lower than the mean FRS values of overweight (8.80±3.39) and obese (13.39±6.24) groups (p<0.001). Waist circumference of individuals with low FRS value (p<0.001) was lower. There was a weak positive correlation between serum copper levels and BMI (r=0.176 p=0.018). When the relationships of other measured trace element levels with BMI and FRS were examined, no significant relationship was found. Conclusion: Cardiovascular risk, waist circumference and cholesterol levels were found to be lower in individuals with normal weight. In addition, a positive correlation was found between serum copper levels and BMI values of individuals. It was observed that serum Se, Zn and Fe values were not related to BMI and FRS values. Therefore, randomized controlled studies are still needed for the determination of serum trace element levels to enter clinical practice in the diagnosis and follow-up of obesity and cardiovascular disease.
Obesity and excess weight predispose to many diseases, especially cardiovascular and endocrinological. Prediction of obesity and its complications is important in diagnosis and treatment. The aim of this study is to determine the serum trace element [copper(Cu), zinc(Zn), iron(Fe) and selenium(Se)] levels in obese and non-obese individuals and to examine the relationship between trace elements by determining the Framingham risk score in these individuals. Materials and methods: The population of this cross-sectional study consisted of individuals who applied to Necmettin Erbakan University Meram Medical Faculty Family Medicine Polyclinic between 01.03.2022 and 31.04.2022. Participants were divided into 3 groups according to their body mass index (BMI) values. Age distribution, the number of male and female individuals, and the number of smokers and non-smokers were tried to be kept similar between the groups. Sociodemographic characteristics, body mass indexes, systolic and diastolic blood pressures, hemogram, lipid panel parameters, Framingham risk score values of the individuals were recorded. The serum iron, zinc, copper and selenium levels of the participants were analyzed by spectrophotometry method in the laboratory of Necmettin Erbakan University Medical Biochemistry Department. The data were evaluated in the Statistical Package for the Social Sciences (SPSS) version 22.0 statistical package program. Statistical significance was accepted as p<0.05. Results: A total of 180 people were included in the study and 50.0% of the individuals were male (n=90). The mean Framingham Risk Score (FRS) of the participants was 9.31±7.99 (1- 37), the mean waist circumference was 95.63±15.08 (61-132) cm, and the mean BMI was 27.58±5.70 (18- 60.55) kg/m2. 33.9% (n=61) of the individuals were normal weight, 33.3% (n=60) were overweight and 32.8% (n=59) were obese. The mean age of normal-weight vii individuals (41.39±9.12) was lower than that of obese individuals (45.69±7.60) (p=0.016). The mean FRS of normal weight individuals (7.84±3.05) was lower than the mean FRS values of overweight (8.80±3.39) and obese (13.39±6.24) groups (p<0.001). Waist circumference of individuals with low FRS value (p<0.001) was lower. There was a weak positive correlation between serum copper levels and BMI (r=0.176 p=0.018). When the relationships of other measured trace element levels with BMI and FRS were examined, no significant relationship was found. Conclusion: Cardiovascular risk, waist circumference and cholesterol levels were found to be lower in individuals with normal weight. In addition, a positive correlation was found between serum copper levels and BMI values of individuals. It was observed that serum Se, Zn and Fe values were not related to BMI and FRS values. Therefore, randomized controlled studies are still needed for the determination of serum trace element levels to enter clinical practice in the diagnosis and follow-up of obesity and cardiovascular disease.
Açıklama
Anahtar Kelimeler
Framingham risk skoru, Obezite, Serum eser element düzeyi, Beden kitle indeksi, Framingham risk score, Obesity, Serum trace element level, Body mass index
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Oğuz, D. (2022). Eser elementlerin obezite ve framingham risk skoru üzerine etkisinin incelenmesi. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Dahili Tıp Bilimleri Bölümü Aile Hekimliği Anabilim Dalı, Konya.
