Synthesis and characterization of new targeted pH-responsive heteroatom-doped hexagonal boron nitride nanosheets for controlled drug release

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dc.contributor.authorGurbuz, Havva Nur
dc.contributor.authorYilmaz, Kubra
dc.contributor.authorIpekci, Hasan H.
dc.contributor.authorUzunoglu, Aytekin
dc.contributor.authorCagil, Esra Maltas
dc.date.accessioned2024-02-23T14:13:18Z
dc.date.available2024-02-23T14:13:18Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractIn this study, sulfur doped hexagonal boron nitride (S-h-BN) and fluorine doped hexagonal boron nitride (F-h-BN) were prepared via the exfoliation and heat treatment of bulk boron nitride (B-BN). Then, Human Serum Albumin (HSA) were immobilized onto the obtained hexagonal boron nitride nanolayer (NLs) surfaces to enhance irinotecan loading, which is a fluorescent molecule having excitation and emission at the wavelengths of 299 nm and 436 nm, respectively. The loading and release properties were studied at different pH values. Whereas the maximum loading amounts were achieved at the pH of 4.0 for all nanosheets, the pH value at which the maximum drug release was observed were found to be different for all samples. The physicochemical characterization of the nanosheets were conducted by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy methods. The XRD and FTIR results indicated the successful synthesis of h-BN and the 2D structure of the nanolayers were imaged using SEM and TEM methods. The F and S content inserted into the h-BN structure was determined to be about 2.45 and 0.1 at. % using the XPS method. In addition, the bonding structre of the modified h-BN monolayers were unraveled by the deconvulation of the XPS results.en_US
dc.description.sponsorshipResearch Foundation of Selcuk Univer- sity (BAP)en_US
dc.description.sponsorshipWe would like to thank The Research Foundation of Selcuk Univer- sity (BAP) for financial support of this work.en_US
dc.identifier.doi10.1016/j.mseb.2023.116909
dc.identifier.issn0921-5107
dc.identifier.issn1873-4944
dc.identifier.scopus2-s2.0-85173580620en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.mseb.2023.116909
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12374
dc.identifier.volume299en_US
dc.identifier.wosWOS:001091068700001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMaterials Science And Engineering B-Advanced Functional Solid-State Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug Deliveryen_US
dc.subjectPharmaceuticalsen_US
dc.subjectHexagonal Boron Nitrideen_US
dc.subjectAlbuminen_US
dc.subjectControlled Drug Deliveryen_US
dc.titleSynthesis and characterization of new targeted pH-responsive heteroatom-doped hexagonal boron nitride nanosheets for controlled drug releaseen_US
dc.typeArticleen_US

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