An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloprotein- ase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients

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dc.contributor.authorDemir, Nazlim Aktug
dc.contributor.authorKirik, Sema Yilmaz
dc.contributor.authorSumer, Sua
dc.contributor.authorUral, Onur
dc.contributor.authorKiratli, Hatice Esranur
dc.contributor.authorVatansev, Husamettin
dc.contributor.authorHayatsal, Esra Paydas
dc.date.accessioned2024-02-23T14:38:24Z
dc.date.available2024-02-23T14:38:24Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackground: The progression of COVID-19 has different clinical presentations, which raises a number of immunological questions. Objectives: This study aimed to investigate MMP-9 and TIMP-1 levels in patients diagnosed with COVID-19 and whether the MMP-9/TIMP-1 ratio is associated with lung involvement in COVID-19.Methods: This study was conducted with 192 patients and 45 healthy controls. ELISA was used to measure the MMP-9 and TIMP-1.Results: The MMP-9 and TIMP-1 levels of the patients were found to be higher than those of the controls. MMP-9 and TIMP-1 were detected more in patients with lung involvement on chest CT scans than in those with no lung involvement on chest CT scans. A comparison of lung involvement levels revealed no difference was found between the groups. The MMP-9/TIMP-1 ratio was 5.8 in the group with lung involvement on chest CT scans and 6.1 in the group without lung involvement on chest CT scans. No difference was found between the two groups. A comparison with respect to lung involvement levels showed that the MMP-9/TIMP-1 ratio difference was found between the groups.Conclusion: Diagnostic and treatment methods targeting MMP-9 activity or neutrophil activation may be important in predict-ing lung involvement in COVID-19 and directing clinical outcomes.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Selcuk University [20301017]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordination Unit of Selcuk University with project number 20301017.en_US
dc.identifier.doi10.4314/ahs.v23i1.5
dc.identifier.endpage43en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue1en_US
dc.identifier.pmid37545954en_US
dc.identifier.scopus2-s2.0-85156182991en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v23i1.5
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16509
dc.identifier.volume23en_US
dc.identifier.wosWOS:000976738200006en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMakerere Univ, Coll Health Sciences,Sch Meden_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCovid-19en_US
dc.subjectMmp-9en_US
dc.subjectTimp-1en_US
dc.titleAn evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloprotein- ase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patientsen_US
dc.typeArticleen_US

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