The Turkish Neonatal Jaundice Online Registry: A national root cause analysis

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dc.contributor.authorErdeve, Omer
dc.contributor.authorOkulu, Emel
dc.contributor.authorOlukman, Ozgur
dc.contributor.authorUlubas, Dilek
dc.contributor.authorBuyukkale, Gokhan
dc.contributor.authorNarter, Fatma
dc.contributor.authorTunc, Gaffari
dc.date.accessioned2024-02-23T14:31:27Z
dc.date.available2024-02-23T14:31:27Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractBackground Neonatal jaundice (NNJ) is common, but few root cause analyses based on national quality registries have been performed. An online registry was established to estimate the incidence of NNJ in Turkey and to facilitate a root cause analysis of NNJ and its complications. Methods A multicenter prospective study was conducted on otherwise healthy newborns born at >= 35 weeks of gestation and hospitalized for only NNJ in 50 collaborator neonatal intensive care units across Turkey over a 1-year period. Patients were analyzed for their demographic and clinical characteristics, treatment options, and complications. Results Of the 5,620 patients enrolled, 361 (6.4%) had a bilirubin level >= 25 mg/dL on admission and 13 (0.23%) developed acute bilirubin encephalopathy. The leading cause of hospital admission was hemolytic jaundice, followed by dehydration related to a lack of proper feeding. Although all infants received phototherapy, 302 infants (5.4%) received intravenous immunoglobulin in addition to phototherapy and 132 (2.3%) required exchange transfusion. The infants who received exchange transfusion were more likely to experience hemolytic causes (60.6% vs. 28.1%) and a longer duration of phototherapy (58.5 +/- 31.7 vs. 29.4 +/- 18.8 h) compared to infants who were not transfused (p < 0.001). The incidence of short-term complications among discharged patients during follow-up was 8.5%; rehospitalization was the most frequent (58%), followed by jaundice for more than 2 weeks (39%), neurological abnormality (0.35%), and hearing loss (0.2%). Conclusions Severe NNJ and bilirubin encephalopathy are still problems in Turkey. Means of identifying at-risk newborns before discharge during routine postnatal care, such as bilirubin monitoring, blood group analysis, and lactation consultations, would reduce the frequency of shortand long-term complications of severe NNJ.en_US
dc.description.sponsorshipTurkish Neonatal Society [3-2015]; Turkish Neonatal Societyen_US
dc.description.sponsorshipThis study was supported by the Turkish Neonatal Society, http://www.neonatology.org.tr, number 3-2015, received by OE. Turkish Neonatal Society funded the studys online registry system. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.doi10.1371/journal.pone.0193108
dc.identifier.issn1932-6203
dc.identifier.issue2en_US
dc.identifier.pmid29474382en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0193108
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15199
dc.identifier.volume13en_US
dc.identifier.wosWOS:000426049500055en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleThe Turkish Neonatal Jaundice Online Registry: A national root cause analysisen_US
dc.typeArticleen_US

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