Aortic stiffness in patients with wilson's disease

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dc.contributor.authorGurbuz, A. S.
dc.contributor.authorOzturk, S.
dc.contributor.authorEfe, S. C.
dc.contributor.authorDemir, K.
dc.date.accessioned2024-02-23T14:37:54Z
dc.date.available2024-02-23T14:37:54Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractAim: Wilson's disease (WD) presents with different phenotypes. Neurologic and liver involvement in WD are well documented. Few reports demonstrated cardiac and vascular involvement. Several studies showed an association between serum copper levels and atherosclerosis. Although WD is the prototype disease of copper metabolism, atherosclerosis has not been studied yet. The aim of this study is to assess aortic stiffness in WD. Materials and Methods: Aortic pulse wave velocity (PWV), augmentation pressure (AP), augmentation index (AIx), central aortic systolic, diastolic, mean, and pulse pressures were measured using SphygmoCor (AtCor Medical) device in 32 patients with WD and 24 healthy controls. Results: Patients with WD and healthy controls were similar in terms of age sex, body mass index (BMI), and liver and kiney functions. However, patients with WD were anemic and thrombocytopenic. Echocardiographic parameters including left ventricular, atrial dimensions, and systolic and diastolic functions were similar between two groups. Patients with WD and healthy controls were compared. Baseline characteristics including age, sex, and BMI did not differ between groups. Central aortic systolic, diastolic, mean, and pulse pressures were similar between the groups. AP, AIx, and PWV did not differ between groups as well. Conclusion: Aortic stiffness in WD was similar in healthy controls.en_US
dc.identifier.doi10.4103/njcp.njcp_578_18
dc.identifier.endpage1125en_US
dc.identifier.issn1119-3077
dc.identifier.issue8en_US
dc.identifier.pmid31417056en_US
dc.identifier.scopus2-s2.0-85070974659en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1120en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_578_18
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16274
dc.identifier.volume22en_US
dc.identifier.wosWOS:000481990500013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAortic Stiffnessen_US
dc.subjectCopper Metabolismen_US
dc.subjectWilson's Diseaseen_US
dc.titleAortic stiffness in patients with wilson's diseaseen_US
dc.typeArticleen_US

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