Hematopoietic Stem Cell Transplantation From Unrelated Donors in 2 Cases of Interleukin-10 Receptor Deficiency: Is Surgery Not a Requirement?

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dc.contributor.authorUygun, Dilara F. Kocacik
dc.contributor.authorUygun, Vedat
dc.contributor.authorDaloglu, Hayriye
dc.contributor.authorOzturkmen, Seda
dc.contributor.authorKarasu, Gulsun
dc.contributor.authorReisli, Ismail
dc.contributor.authorSayar, Ersin
dc.date.accessioned2024-02-23T14:21:16Z
dc.date.available2024-02-23T14:21:16Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractMutations in interleukin-10 and its receptors cause infantile inflammatory bowel disease (IBD), a hyperinflammatory disorder characterized by severe, treatment-refractory colitis, multiple abscesses, and enterocutaneous fistulas. Patients with infantile IBD often require several surgical interventions, including complete colectomy, and hematopoietic stem cell transplantation is currently the only known medical therapy. Traditionally, operative management has been preferred before stem cell transplantation because of the latter's increased susceptibility to procedural complications; however, surgical intervention could be delayed, and possibly reconsidered, because our 2 patients with infantile IBD demonstrated a rapid response to treatment via engraftment.en_US
dc.identifier.doi10.1097/MPH.0000000000001165
dc.identifier.endpage66en_US
dc.identifier.issn1077-4114
dc.identifier.issn1536-3678
dc.identifier.issue1en_US
dc.identifier.pmid29683948en_US
dc.identifier.scopus2-s2.0-85059291700en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://doi.org/10.1097/MPH.0000000000001165
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13526
dc.identifier.volume41en_US
dc.identifier.wosWOS:000455186000031en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Pediatric Hematology Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHematopoietic Stem Cell Transplantationen_US
dc.subjectIl-10 Deficiencyen_US
dc.subjectAnal Fistulaen_US
dc.titleHematopoietic Stem Cell Transplantation From Unrelated Donors in 2 Cases of Interleukin-10 Receptor Deficiency: Is Surgery Not a Requirement?en_US
dc.typeArticleen_US

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