Maternal generalized anxiety disorder during pregnancy and fetal brain development: A comparative study on cord blood brain-derived neurotrophic factor levels

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dc.contributor.authorUguz, Faruk
dc.contributor.authorSonmez, Erdem Onder
dc.contributor.authorSahingoz, Mine
dc.contributor.authorGokmen, Zeynel
dc.contributor.authorBasaran, Mustafa
dc.contributor.authorGezginc, Kazim
dc.contributor.authorSonmez, Gulsum
dc.date.accessioned2024-02-23T14:13:02Z
dc.date.available2024-02-23T14:13:02Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractObjectives: The study aimed to investigate whether maternal GAD during pregnancy affects fetal circulating brain-derived neurotrophic factor (BDNF), which plays important roles in neuronal development, by comparing cord blood BDNF levels in newborn infants of women with and without GAD. Methods: Study sample included 19 women with GAD and 25 women without any psychiatric disorder. GAD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of BDNF level was obtained from the umbilical cord during delivery. Results: Cord blood BDNF levels in newborn infants of healthy women were approximately two-fold compared to newborn infants of women with GAD, and the difference was statistically significant. The duration of GAD during pregnancy was the only variable correlating with cord blood BDNF levels. Conclusions: The study results imply that prolonged maternal GAD during pregnancy may negatively influence neurodevelopment of the fetus through lower levels of circulating BDNF. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipAstraZeneca Inc.en_US
dc.description.sponsorshipThe BDNF kit used in the study was funded by AstraZeneca Inc.en_US
dc.identifier.doi10.1016/j.jpsychores.2013.04.010
dc.identifier.endpage350en_US
dc.identifier.issn0022-3999
dc.identifier.issn1879-1360
dc.identifier.issue4en_US
dc.identifier.pmid24119941en_US
dc.identifier.scopus2-s2.0-84885373929en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage346en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychores.2013.04.010
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12268
dc.identifier.volume75en_US
dc.identifier.wosWOS:000325838400009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal Of Psychosomatic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain-Derived Neurotrophic Factoren_US
dc.subjectPregnancyen_US
dc.subjectAnxietyen_US
dc.titleMaternal generalized anxiety disorder during pregnancy and fetal brain development: A comparative study on cord blood brain-derived neurotrophic factor levelsen_US
dc.typeArticleen_US

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