Serum trace elements in obese women with or without diabetes

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dc.contributor.authorYerlikaya, F. Humeyra
dc.contributor.authorToker, Aysun
dc.contributor.authorAribas, Alpay
dc.date.accessioned2024-02-23T14:45:43Z
dc.date.available2024-02-23T14:45:43Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractBackground & objectives: Relationship of trace elements with obesity and diabetes is complex, alterations in their metabolism can be induced by the diseases and their complications. To study the role of the trace elements in diabetes and obesity, serum trace elements levels (Cr, Se, Fe, Zn, Cu and Mn) were measured in obese women with or without diabetes as well as healthy women. Further, correlation between serum trace elements levels and glucose, insulin, homeostasis model assessment (HOMA-IR), glycated haemoglobin (HbA(1)c), body mass index (BMI), waist circumferences, waist -to -hip ratio and high-sensitivity C-reactive protein (hsCRP) were also determined in these women. Methods: This study was performed with morbidly obese (BMI >40 kg/m(2)) women with diabetes (n=41), without diabetes (n=45) and 50 healthly non obese women. Anthropometric measurements were taken and levels of serum Zn, Cr, Fe Cu and Mn were determined. Biochemical parameters included serum glucose, insulin, lipids, haemoglobin, hsCRP and HbA1C. Results: The levels of Zn (P<0.001), Mn (P<0.05), Fe (P<0.05) were significantly lower and the level of Cu (P<0.001) and Cu / Zn ratio (P<0.05) were significantly higher in the diabetic obese women than those of the healthy women. Also, the levels of Zn and Fe were significantly lower and the levels of Cu were significantly higher in the non diabetic obese women than those of the healthy group. Serum Zn levels negatively and serum Cu levels positively correlated with anthropometric values in diabetic and non diabetic obese women. Further, serum Zn, Mn and Cr levels negatively correlated and serum Se levels positively correlated glycaemia control parameters in diabetic obese women. In addition, serum Zn levels negatively correlated with hsCRP in diabetic and nondiabetic obese females. Interpretation & conclusions: Our findings showed significant association between Zn and Fe deficiencies and obesity. Also, obese women with diabetes may be at a greater risk of developing imbalances and deficiencies of trace elements compared with obese women without diabetes.en_US
dc.identifier.endpage345en_US
dc.identifier.issn0971-5916
dc.identifier.pmid23563378en_US
dc.identifier.scopus2-s2.0-84875547765en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage339en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17578
dc.identifier.volume137en_US
dc.identifier.wosWOS:000330852200013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChromiumen_US
dc.subjectDiabetesen_US
dc.subjectIronen_US
dc.subjectObesityen_US
dc.subjectSeleniumen_US
dc.subjectTrace Elementen_US
dc.subjectZincen_US
dc.titleSerum trace elements in obese women with or without diabetesen_US
dc.typeArticleen_US

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