The Predictive Value of Platelet/Lymphocyte Ratio in Hemodialysis Patients With Erythropoietin Resistance

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dc.contributor.authorTaymez, Dilek Guven
dc.contributor.authorUcar, Esma
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorUcar, Ramazan
dc.contributor.authorAfsar, Baris
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorTurk, Suleyman
dc.date.accessioned2024-02-23T14:24:00Z
dc.date.available2024-02-23T14:24:00Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractThe most important cause of anemia in CKD is relative deficiency of erythropoietin (EPO) secretion from the diseased kidney and EPO therapy has become the standard treatment for anemia of CKD. However, some patients do not respond well to erythropoiesis stimulating agent (ESA), so-called ESA resistance. One of the most important causes of ESA resistance is chronic inflammation in hemodialysis (HD) patients. ESA hyporesponsiveness index (EHRI), calculated as the weekly dose of EPO divided by kilograms of body weight divided by the hemoglobin level, and has been considered useful to assess the EPO resistance. Neutrophil/lymphocyte (NLR) ratio and platelet/lymphocyte ratio (PLR) were also found to be associated with inflammation in HD patients. However, the relationship between NLR, PLR and EHRI has not been investigated before. HD patients underwent medical history taking, physical examination, calculation of dialysis adequacy and biochemical analysis and calculation of EHRI. Logarithmically converted EHRI (logEHRI) was correlated only with hemoglobin (r -0.381, P< 0.0001) and PLR (r= 0.227, P=0.021) but not with NLR. Comparison of PLR among 25th, 50th and 75th percentile of EHRI showed that PLR levels increased going from the 25th to 75(th) percentile (P=0.032). Posthoc analysis revealed that 25-75th percentile (P=0.014) and 50-75th percentile (P=0.033) were different with respect to PLR. In linear regression analysis, PLR (standardized = 0.296, confidence interval: 0.000-0.001, P=0.003) was independently associated with logEHRI. We found that PLR was independently associated with EHRI in HD patients. PLR, which is quite a simple and cheap method, may guide clinicians for detecting EPO resistance.en_US
dc.identifier.doi10.1111/1744-9987.12380
dc.identifier.endpage121en_US
dc.identifier.issn1744-9979
dc.identifier.issn1744-9987
dc.identifier.issue2en_US
dc.identifier.pmid26929254en_US
dc.identifier.scopus2-s2.0-84959573954en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage118en_US
dc.identifier.urihttps://doi.org/10.1111/1744-9987.12380
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13757
dc.identifier.volume20en_US
dc.identifier.wosWOS:000373933300003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofTherapeutic Apheresis And Dialysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErythropoietin Resistanceen_US
dc.subjectHemodialysisen_US
dc.subjectInflammationen_US
dc.subjectPlateleten_US
dc.subjectLymphocyte Ratioen_US
dc.titleThe Predictive Value of Platelet/Lymphocyte Ratio in Hemodialysis Patients With Erythropoietin Resistanceen_US
dc.typeArticleen_US

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