Drug Dose Adjustment in Dialysis Patients Admitted in Clinics Other Than Internal Medicine

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dc.contributor.authorSolak, Yalcin
dc.contributor.authorBiyik, Zeynep
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorCiray, Hilal
dc.contributor.authorCizmecioglu, Ahmet
dc.contributor.authorTonbul, Halil Zeki
dc.date.accessioned2024-02-23T14:21:16Z
dc.date.available2024-02-23T14:21:16Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractMany drugs that are administered during hospitalization are metabolized or excreted through kidneys, consequently require dosage adjustment. We aimed to investigate inappropriate prescription of drugs requiring renal dose adjustment (RDA) in various surgical and medical inpatient clinics. We retrospectively determined dialysis patients hospitalized between January 2007 and December 2010. Inpatient clinics, including cardiology, pulmonary medicine, neurology, infectious diseases (medical clinics) and cardiovascular surgery, orthopedics, general surgery, obstetrics and gynecology, and neurosurgery (surgical clinics), were screened via electronic database. Total and RDA medications were determined. RDA drugs correctly adjusted to creatinine clearance were labeled as RDA-A (appropriate), otherwise as RDA-I (inappropriate). Renal doses of RDA medications were based on the American College of Physicians Drug Prescribing in Renal Failure, fifth Edition. Two hundred seventeen hospitalization records of 172 dialysis patients (92 men and 80 women) were included in the analysis. Mean age of patients was 59.4 +/- 14.6 years, and the mean hospitalization duration was 8.5 +/- 7.8 days. In total, 247 (84.3%, percentage in drugs requiring dose adjustment) and 175 (46.2%) drugs have been inadequately dosed in surgical and medical clinics, respectively. The percentage of patients to whom at least 1 RDA-I drug was ordered was 92% and 91.4% for surgical and medical clinics, respectively (P > 0.05). Nephrology consultation numbers were 8 (7.1%) in surgical and 32 (30.4%) in medical clinics. The most common RDA-I drugs were aspirin and famotidine. A significant portion of RDA drugs was ordered inappropriately both in surgical and medical clinics. Nephrology consultation rate was very low. Measures to increase physician awareness are required to improve results.en_US
dc.description.sponsorshipERA-EDTA fellowship programen_US
dc.description.sponsorshipDr Gaipov received grant support from the ERA-EDTA fellowship program. No sources of funding were used to conduct this study or in the preparation of this manuscript.en_US
dc.identifier.doi10.1097/MJT.0b013e3182a4ef81
dc.identifier.endpageE73en_US
dc.identifier.issn1075-2765
dc.identifier.issn1536-3686
dc.identifier.issue1en_US
dc.identifier.pmid23982697en_US
dc.identifier.scopus2-s2.0-84955632555en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE68en_US
dc.identifier.urihttps://doi.org/10.1097/MJT.0b013e3182a4ef81
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13522
dc.identifier.volume23en_US
dc.identifier.wosWOS:000368122200010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal Of Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemodialysisen_US
dc.subjectRenal Dose Adjustmenten_US
dc.subjectInpatient Clinicsen_US
dc.titleDrug Dose Adjustment in Dialysis Patients Admitted in Clinics Other Than Internal Medicineen_US
dc.typeArticleen_US

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