Effect of Zinc and Melatonin on Oxidative Stress and Serum Inhibin-B Levels in a Rat Testicular Torsion-Detorsion Model

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dc.contributor.authorSemercioz, Atilla
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorAvunduk, Mustafa Cihat
dc.date.accessioned2024-02-23T13:56:02Z
dc.date.available2024-02-23T13:56:02Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractThe present study was aimed to examine the effects of 3-week zinc and melatonin administration on testicular tissue injury and serum Inhibin-B levels caused by unilateral testicular torsion-detorsion in rats. The study was performed on 60 Wistar Albino-type adult male rats. The animals were allocated to 6 groups in equal numbers. 1. Control; 2. Sham; 3. Ischemia-reperfusion; 4. Zinc + ischemia-reperfusion; 5. Melatonin + ischemia-reperfusion; 6. Zinc + melatonin + ischemia-reperfusion. Zinc and melatonin were administered before ischemia-reperfusion at doses of 5 and 3 mg/kg respectively, by intraperitoneal route for a period of 3 weeks. Testicular torsion-detorsion procedures consisted of ischemia for 1 h and then reperfusion for another hour of the left testis. Blood and testicular tissue samples were collected to analyze erythrocyte and tissue GSH and plasma and tissue MDA, Inhibin-B levels. The highest erythrocyte and testis GSH values were found in zinc, melatonin, and zinc + melatonin groups (p < 0.001). Torsion-detorsion group has significantly lower erythrocyte GSH levels and higher plasma MDA values (p < 0.001). Serum inhibin-B and spermatogenic activity levels in the torsion-detorsion group were also significantly lower than those in the other groups (p < 0.001). However, zinc-, melatonin-, and melatonin + zinc-supplemented groups have higher inhibin-B and spermatogenetic activity (p < 0.001). The results of the study show that zinc, melatonin, and melatonin + zinc administration partially restores the increased oxidative stress, as well as the reduced inhibin-B and spermatogenic activity levels in testes ischemia-reperfusion in rats. Suppressed inhibin-B levels in the testicular tissue may be a marker of oxidative stress.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University (SUBAPK) [12202010]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK; Project No. 12202010).en_US
dc.identifier.doi10.1007/s10528-017-9826-5
dc.identifier.endpage409en_US
dc.identifier.issn0006-2928
dc.identifier.issn1573-4927
dc.identifier.issue5.Hazen_US
dc.identifier.pmid29094225en_US
dc.identifier.scopus2-s2.0-85032789037en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://doi.org/10.1007/s10528-017-9826-5
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11062
dc.identifier.volume55en_US
dc.identifier.wosWOS:000415989300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofBiochemical Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTestis Torsion-Detorsionen_US
dc.subjectZincen_US
dc.subjectMelatoninen_US
dc.subjectTissue Injuryen_US
dc.subjectInhibin-Ben_US
dc.titleEffect of Zinc and Melatonin on Oxidative Stress and Serum Inhibin-B Levels in a Rat Testicular Torsion-Detorsion Modelen_US
dc.typeArticleen_US

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