Rosuvastatin-induced responses in calf cardiac vein

Basit Öğe Kaydı
dc.contributor.authorNurullahoglu-Atalik, K. E.
dc.contributor.authorOz, M.
dc.contributor.authorShafiyi, A.
dc.date.accessioned2024-02-23T14:37:58Z
dc.date.available2024-02-23T14:37:58Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE: The effects of Rho-kinase inhibitors on vasodilatation induced by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor rosuvastatin (10(-9)-10(-4)M) on 5-HT-precontracted calf cardiac vein and the role of endothelium in these effects were analyzed. MATERIAL AND METHODS: Cardiac vein ring preparations were suspended in organ baths containing 25 ml of Krebs Henseleit solution, maintained at 37 degrees C and continuously gassed with 95 % O-2-5 % CO2. At the end of the resting period, the cardiac vein preparations were contracted with 10(-6) M 5-HT. After the contraction had reached a steady state, rosuvastatin was added to the organ bath cumulatively (10(-9)-10(-4)M). RESULTS: Rosuvastatin relaxed the cardiac vein rings in general while the degree of relaxation was greater in those with endothelium and lower in those without it. HA1077 [1-(5-isoquinolinesulfonyl)-homopiperazine] (Fasudil, 10(-6) M) and Y-27632 [(+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexane carboxamide dihydrochloride] (10(-6) M) incubation increased the rosuvastatin-induced relaxation only in the presence of endothelium. CONCLUSIONS: The results demonstrate for the first time that in calf cardiac vein, rosuvastatin induced endothelium-dependent relaxations while Rho-kinase inhibition increased these relaxations in the presence of endothelium layer (Fig. 3, Ref. 44). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipScientific Research Foundation of Necmettin Erbakan Universityen_US
dc.description.sponsorshipThis study is supported by the Scientific Research Foundation of Necmettin Erbakan University.en_US
dc.identifier.doi10.4149/BLL_2015_095
dc.identifier.endpage498en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue8en_US
dc.identifier.pmid26350090en_US
dc.identifier.scopus2-s2.0-84962269374en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage494en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_095
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16315
dc.identifier.volume116en_US
dc.identifier.wosWOS:000361083000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalf Cardiac Veinen_US
dc.subjectEndothelium-Dependent Relaxationen_US
dc.subjectRho-Kinaseen_US
dc.subjectRosuvastatinen_US
dc.titleRosuvastatin-induced responses in calf cardiac veinen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu