A Comparison of Ketamine and Paracetamol for Preventing Remifentanil Induced Hyperalgesia in Patients Undergoing Total Abdominal Hysterectomy

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dc.contributor.authorYalcin, Naime
dc.contributor.authorUzun, Sema Tuncer
dc.contributor.authorReisli, Ruhiye
dc.contributor.authorBorazan, Hale
dc.contributor.authorOtelcioglu, Seref
dc.date.accessioned2024-02-23T14:44:49Z
dc.date.available2024-02-23T14:44:49Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractBackground: The aim of this prospective, randomized, placebo-controlled study was to compare the effects of ketamine and paracetamol on preventing remifentanil induced hyperalgesia. Methods: Ninety patients undergoing total abdominal hysterectomy were randomly assigned to one of three groups to receive (I) either saline infusion; (II) 0.5 mg/kg ketamine iv bolus or (III) 1000 mg iv paracetamol infusion before induction of anesthesia. Until the skin closure, anesthesia was maintained with 0.4 mu g/kg/min remifentanil infusion in all groups, additionally Group II received 5 mu g/kg/min ketamine infusion. Pressure pain thresholds were measured the day before surgery during the preoperative visit for baseline measurements and repeated postoperatively at 24 and 48 hours (hrs). Pressure pain thresholds were established by digital algometer on three different peri-incisional regions for calculating mean pressure pain threshold values. The visual analogue scale (VAS), sedation scores, total morphine consumption and side effects were assessed postoperatively. Results: Demographic characteristics, duration of surgery and anesthesia were similar in the three groups. Pain thresholds at the incision region were significantly lower at 24 and 48 hrs postoperatively in Group I than the other Groups (p<0.05). In Group., pain thresholds were lower compared with preoperative baseline values. Thresholds in Group II and Group III were higher compared with preoperative baseline values (p<0.05) The VAS scores at all evaluation times were significantly higher in Group. when compared to Group.. and at 2, 4, 6,12 hrs were higher in Group I than Group III (p<0.05). The morphine consumption was higher in Group III at 24 and 48 hrs postoperatively (p<0.05). Conclusion: It was shown that ketamine and paracetamol were both effective in preventing remifentanil induced hyperalgesia.en_US
dc.identifier.doi10.7150/ijms.4222
dc.identifier.endpage333en_US
dc.identifier.issn1449-1907
dc.identifier.issue5en_US
dc.identifier.pmid22745573en_US
dc.identifier.scopus2-s2.0-84868023741en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage327en_US
dc.identifier.urihttps://doi.org/10.7150/ijms.4222
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17129
dc.identifier.volume9en_US
dc.identifier.wosWOS:000306706800002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIvyspring Int Publen_US
dc.relation.ispartofInternational Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRemifentanilen_US
dc.subjectKetamineen_US
dc.subjectParacetamolen_US
dc.subjectPostoperative Painen_US
dc.subjectHyperalgesiaen_US
dc.titleA Comparison of Ketamine and Paracetamol for Preventing Remifentanil Induced Hyperalgesia in Patients Undergoing Total Abdominal Hysterectomyen_US
dc.typeArticleen_US

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