Increased expression of ubiquitin C-terminal hydrolase L1 in astrocytomas of ascending grades

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dc.contributor.authorIzci, Emir Kaan
dc.contributor.authorKeskin, Fatih
dc.contributor.authorErdi, Fatih
dc.contributor.authorKaya, Bulent
dc.contributor.authorKaratas, Yasar
dc.contributor.authorFeyzioglu, Bahadir
dc.contributor.authorFindik, Siddika
dc.date.accessioned2024-02-23T14:21:14Z
dc.date.available2024-02-23T14:21:14Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackground:The ubiquitin-proteasome pathway controls the monitoring and degradation of important proteins and is involved in several cellular processes, such as development, differentiation, and transcriptional regulation. Recent evidence has shown that ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1), a member of the deubiquitinating enzyme family that removes ubiquitin from protein substrates, is overexpressed in many types of cancer. Aim:This study thus examined the expression of UCH-L1 in human astrocytoma tissues. Material and methods:Formalin-fixed, paraffin-embedded astrocytoma samples were obtained from 40 patients, after which histopathological examination, typing, and grading were performed. The study group included 10 histologically normal brain tissues, which served as the control group, and 10 WHO grade II, 10 WHO grade III, and 10 WHO grade IV (glioblastoma) samples. Normal brain tissue samples were obtained from the histologically normal, non-tumoral portion of the pathology specimens. UCH-L1 expression was evaluated using quantitative reverse transcription-polymerase chain reaction and immunohistochemistry. Results:Astrocytoma tissues exhibited higher UCH-L1 expression compared to the control group. UCH-L1 overexpression increased significantly together with the increase in astrocytoma grades (from II to IV). Conclusion:UCH-L1 could be a good diagnostic and therapeutic marker for determining astrocytoma development and progression.en_US
dc.identifier.doi10.1097/MD.0000000000034132
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue26en_US
dc.identifier.pmid37390278en_US
dc.identifier.scopus2-s2.0-85164231652en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000034132
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13507
dc.identifier.volume102en_US
dc.identifier.wosWOS:001021744000049en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAstrocytomaen_US
dc.subjectExpressionen_US
dc.subjectGlioblastomaen_US
dc.subjectUbiquitin Carboxy-Terminal Hydrolase-L1en_US
dc.titleIncreased expression of ubiquitin C-terminal hydrolase L1 in astrocytomas of ascending gradesen_US
dc.typeArticleen_US

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