Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea

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dc.contributor.authorSaglam, Gozde Demirci
dc.contributor.authorZamani, Adil
dc.contributor.authorYosunkaya, Sebnem
dc.contributor.authorKilinc, Ibrahim
dc.date.accessioned2024-02-23T14:37:23Z
dc.date.available2024-02-23T14:37:23Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: Obstructive sleep apnea (OSA) is associated with serious cardiometabolic risks. Early diagnosis and treatment compliance are important. For this purpose, research is being carried out on biomarkers associated with the pathogenesis of the disease. We aimed to investigate whether serum S100A12 and S100B proteins could be used as biochemical markers in OSA patients to determine disease presence and severity. Materials and methods: A total of 60 (16 women, 44 men) patients with OSA and 50 (20 women, 30 men) controls were enrolled in this cross-sectional study. Each subject included in the study underwent full-night polysomnography (PSG). The presence and severity of OSA was assessed with the apnea-hypopnea index (AHI). In the OSA group, 17 cases were mild, 18 were moderate, and 25 were severe. The serum levels of S100A12 and S100B were measured using the enzyme-linked immunosorbent assay (ELISA) technique. These protein levels were compared using Student's t-test in the patient and control groups. Spearman's rho correlation coefficients and corresponding P-values were calculated to determine the correlations between these protein levels and polysomnographic parameters. For evaluating the association between OSA and biomarkers, as well as possible confounding factors with S100A12 and S100B, we employed multiple linear regression analyses for the patients with OSA. Results: Serum levels of S100A12 and S100B were higher in patients than those in controls (P = 0.01 and P = 0.005, respectively), and a significant correlation was determined between S100A12 and S100B values and AHI (P = 0.0001; P = 0.0001), sleep time with SpO(2) < 90% (P = 0.032; P = 0.01), minimum SpO(2) during sleep (P = 0.019; P = 0.007), and oxygen desaturation index (ODI) (P = 0.001; P = 0.0001). In the linear regression analysis, AHI was independently related with both S100A12 (P < 0.0001) and S100B (P = 0.011). Receiving operating curves (ROC) identified patients with OSA: AUC for S100A12 = 0.643; AUC for S100B = 0.655 (P < 0.05). Conclusion: Serum levels of S100B and S100A proteins have high diagnostic performance in OSA and are independent predictors of OSA presence and severity.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Coordination Center [141518016]en_US
dc.description.sponsorshipThis study was financially supported by the Necmettin Erbakan University Scientific Research Coordination Center (project number: 141518016).en_US
dc.identifier.doi10.3906/sag-1806-147
dc.identifier.endpage754en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid31035738en_US
dc.identifier.scopus2-s2.0-85070302999en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage746en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1806-147
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16079
dc.identifier.volume49en_US
dc.identifier.wosWOS:000471902200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObstructive Sleep Apneaen_US
dc.subjectS100a12 Proteinen_US
dc.subjectS100b Proteinen_US
dc.titleSerum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apneaen_US
dc.typeArticleen_US

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