Vitamin E partially ameliorates cyclophosphamide-induced nephrotoxicity in rats

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dc.contributor.authorCuce, Gokhan
dc.contributor.authorEsen, Haci Hasan
dc.contributor.authorKoc, Tugba
dc.contributor.authorCanbaz, Halime Tuba
dc.contributor.authorLimandal, Cisem
dc.contributor.authorKalkan, Serpil
dc.contributor.authorGurbilek, Mehmet
dc.date.accessioned2024-02-23T14:48:46Z
dc.date.available2024-02-23T14:48:46Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractPurpose: Cyclophosphamide (CP) is a widely used anti chemotherapeutic drug, which causes nephrotoxicity due to its toxic metabolites. This study was carried out to assess the effects of vitamin E on cyclophosphamide induced renal toxicity in rats. Model: Twenty-eight Wistar albino rats were assigned to four groups, which were given 20 mg/kg CP, 20 mg/kg CP + 100 mg/kg vitamin E, 100 mg/kg vitamin E, or 20 mg/kg isotonic sodium chloride solution intraperitoneally each day for 7 days. Effects were assessed by histology of the kidney, TUNEL assay and measurement of serum uric acid and creatinine. Results: Cyclophosphamide significantly increased glomerular inflammation, edema, congestion and tubular degeneration, TUNEL positive cells, while addition of vitamin E significantly decreased glomerular inflammation, edema and TUNEL positive cells. Cyclophosphamide did not affect urea and creatinine levels, which may due to the absence of renal necrosis. Conclusion: Vitamin E application appears to partially ameliorate Cyclophosphamide induced renal toxicity.en_US
dc.identifier.endpage145en_US
dc.identifier.issn1129-8723
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85016263012en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage140en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17832
dc.identifier.volume18en_US
dc.identifier.wosWOS:000380132900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofProgress In Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKidneyen_US
dc.subjectCyclophosphamideen_US
dc.subjectVitamin Een_US
dc.subjectTunelen_US
dc.titleVitamin E partially ameliorates cyclophosphamide-induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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