Is There Any Association Between Use of Antidepressants and Preeclampsia or Gestational Hypertension? A Systematic Review of Current Studies

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dc.contributor.authorUguz, Faruk
dc.date.accessioned2024-02-23T14:21:11Z
dc.date.available2024-02-23T14:21:11Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractObjective: Hypertension in pregnant women is an important medical problem, which can cause morbidity and mortality in the fetus. This study reviewed the current literature examining the potential relationship between use of antidepressants during pregnancy and preeclampsia or gestational hypertension. Methods: PubMed was searched for English-language reports between January 1, 1995, and December 31, 2015, by using combinations of key words pregnancy, pregnancy complications, preeclampsia, gestational hypertension, and antidepressants. Studies that reported the diagnosis of preeclampsia or gestational hypertension and use of antidepressant were included in the review. Results: A total of 7 relevant studies that met the review criteria were examined. The studies reported that compared with nonusers adjusted relative risk of preeclampsia or gestational hypertension in antidepressant users was 1.28 to 1.53 for any antidepressant, 1.05 to 3.16 for selective serotonin reuptake inhibitors, 1.49 to 1.95 for selective serotonin-norepinephrine reuptake inhibitors, and 0.35 to 3.23 for tricyclic antidepressants. Consistently, antidepressant use during the second trimester of pregnancy was associated with increased risk of preeclampsia or gestational hypertension. However, possible contribution of severity, type, and comorbidity of underlying anxiety or depressive disorders is unclear in the current studies. Conclusions: Although some studies have suggested a moderately increased risk in pregnancy-specific hypertensive disorders with antidepressant treatment, the current data do not allow a definitive conclusion on this topic, because the studies have many methodological limitations. In addition, the effects of untreated depression or anxiety disorders cannot be disentangled from the results.en_US
dc.identifier.doi10.1097/JCP.0000000000000618
dc.identifier.endpage77en_US
dc.identifier.issn0271-0749
dc.identifier.issn1533-712X
dc.identifier.issue1en_US
dc.identifier.pmid27941417en_US
dc.identifier.scopus2-s2.0-85003823264en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.1097/JCP.0000000000000618
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13477
dc.identifier.volume37en_US
dc.identifier.wosWOS:000391838500015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectAntidepressantsen_US
dc.subjectPregnancyen_US
dc.titleIs There Any Association Between Use of Antidepressants and Preeclampsia or Gestational Hypertension? A Systematic Review of Current Studiesen_US
dc.typeReview Articleen_US

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