Neutrophil-to-lymphocyte ratio is a prognostic predictor in emergency department patients with cutaneous adverse drug reaction

Basit Öğe Kaydı
dc.contributor.authorDundar, Zerrin Defne
dc.contributor.authorDaye, Munise
dc.date.accessioned2024-02-23T14:02:03Z
dc.date.available2024-02-23T14:02:03Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective: We aimed to evaluate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in emergency de-partment (ED) patients with cutaneous adverse drug reactions to identify the severe patients at an early stage. Methods: In this retrospective study, patients aged 18 and over who admitted to the ED of a university hospital with the diagnosis of cutaneous adverse drug reaction were included. For included patients, clinical findings and ED admission complete blood count results were recorded. The primary outcome was hospitalization and the secondary outcome was the type of drug reaction. Results: A total of 135 patients were included in the study. The median age of patients was 50 (36-64) years. There was no significant difference between the patients hospitalized and discharged from the ED in terms of age and gender (p = 0.340 and p = 0.762, respectively). There was no significant difference between hospital-ized and discharged patients in terms of complete blood count parameters (p > 0.05, for all). The median NLR of hospitalized patients was significantly higher than that of patients discharged from the ED (6.13 vs. 3.69, p = 0.006). The median NLR of the patients with erythema multiform/Steven Johnson syndrome/toxic epider-mal necrosis was significantly higher than the NLR of the patients with maculopapular and fixed drug erup-tions (p = 0.022 and p = 0.015, respectively). The area under the curve value of NLR in predicting hospitalization was 0.640 (0.546-0.734). For 8.4 of NLR cutoff value, specificity was 83.9%. Conclusion: NLR is a useful and simple prognostic parameter as an indicator of systemic inflammatory involve-ment in ED patients with cutaneous adverse drug reactions. NLR is a useful parameter for deciding which patient will be admitted to the hospital in that patient group. (c) 2021 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.ajem.2021.05.029
dc.identifier.endpage283en_US
dc.identifier.issn0735-6757
dc.identifier.issn1532-8171
dc.identifier.pmid34020362en_US
dc.identifier.scopus2-s2.0-85105940392en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2021.05.029
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11554
dc.identifier.volume47en_US
dc.identifier.wosWOS:000686108000049en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal Of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdverse Drug Reactionen_US
dc.subjectNeutrophilen_US
dc.subjectLymphocyteen_US
dc.subjectEmergencyen_US
dc.subjectDermatologyen_US
dc.titleNeutrophil-to-lymphocyte ratio is a prognostic predictor in emergency department patients with cutaneous adverse drug reactionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu