Accelerated atherosclerosis in patients with common variable immunodeficiency: Is it overlooked or absent?

Basit Öğe Kaydı
dc.contributor.authorUcar, Ramazan
dc.contributor.authorArslan, Sevket
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorCaliskaner, Ahmet Zafer
dc.date.accessioned2024-02-23T14:13:12Z
dc.date.available2024-02-23T14:13:12Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractCommon variable immunodeficiency (CVID) is a heterogeneous primary deficiency characterized by hypogammaglobulinemia, recurrent infections, and an increased risk of autoimmune disease and malignancy, and so chronic inflammation. Cardiovascular disease is the leading cause of mortality in the general population. Recent studies have suggested that chronic inflammation is an important player in the pathogenesis of CVID. Accelerated atherosclerosis due to ongoing inflammation from recurrent infections and autoimmunity is an expected clinical entity in patients with CVID. However, cardiovascular mortality as a cause of death in CVID series is either absent or minor. We hypothesized that accelerated atherosclerosis and cardiovascular disease are overlooked by clinicians, or atherosclerosis is really lower than that in the general population that may be prevented by some factors such as life-long immunoglobulin replacement treatment. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.mehy.2015.07.002
dc.identifier.endpage487en_US
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.issue4en_US
dc.identifier.pmid26182977en_US
dc.identifier.scopus2-s2.0-84942505522en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage485en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2015.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12347
dc.identifier.volume85en_US
dc.identifier.wosWOS:000361860800019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleAccelerated atherosclerosis in patients with common variable immunodeficiency: Is it overlooked or absent?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu