Caging of Bodipy Photosensitizers through Hydrazone Bond Formation and their Activation Dynamics

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dc.contributor.authorSay, Busra
dc.contributor.authorTatar, Beytullah
dc.contributor.authorUzulmez, Betul
dc.contributor.authorBakirci, Melike Ebrar
dc.contributor.authorGulseren, Gulcihan
dc.contributor.authorCakmak, Yusuf
dc.date.accessioned2024-02-23T12:06:42Z
dc.date.available2024-02-23T12:06:42Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractThree unique hydrazone-based small-molecule-activatable photosensitizers were designed and synthesized. Two of them work efficiently in a low-pH environment, resembling the microenvironment of the cancerous tissues. The activation pathway is unique and based on hydrazone bond cleavage. They were investigated through in vitro cellular studies in aggressive cancer lines, and tumor-specific culture conditions successfully initiated the cleavage and activation of the cytotoxic singlet oxygen generation in the relevant time period. The interesting photophysical characteristics of the alpha- and beta-substituted hydrazone derivatives of the Bodipy structures and their mild hydrolysis methodologies were also investigated successfully.en_US
dc.identifier.doi10.1002/cmdc.202300199
dc.identifier.issn1860-7179
dc.identifier.issn1860-7187
dc.identifier.issue13en_US
dc.identifier.pmid37078232en_US
dc.identifier.scopus2-s2.0-85156109962en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/cmdc.202300199
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10552
dc.identifier.volume18en_US
dc.identifier.wosWOS:000979120800001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemmedchemen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSensitizersen_US
dc.subjectSinglet Oxygenen_US
dc.subjectHydrazonesen_US
dc.subjectCleavage Reactionsen_US
dc.titleCaging of Bodipy Photosensitizers through Hydrazone Bond Formation and their Activation Dynamicsen_US
dc.typeArticleen_US

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