Soluble TWEAK independently predicts atherosclerosis in renal transplant patients

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dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorTonbul, Halil Zeki
dc.contributor.authorErdur, Fatih Mehmet
dc.contributor.authorToker, Aysun
dc.contributor.authorBiyik, Zeynep
dc.contributor.authorOzbiner, Huseyin
dc.contributor.authorGaipov, Abduzhappar
dc.date.accessioned2024-02-23T14:27:16Z
dc.date.available2024-02-23T14:27:16Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractBackground: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intima-media thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in CKD patients. A novel markers, soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and neutrophil-to-lymphocyte ratio (NLR) were introduced as potential markers in inflammatory disorders including CKD. The role of Rtx in terms of atherogenesis is still unclear. We aimed to investigate the relationship between sTWEAK, NLR and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects. Methods: Cross-sectional analysis in which CIMT measurements, NLR and serum TWEAK levels were assessed in 70 Rtx patients (29 females; mean age, 40.6 +/- 12.4 years) and 25 healthy subjects (13 females, mean age; 37.4 +/- 8.8 years). Results: sTWEAK levels were significantly decreased (p=0.01) and hs-CRP, NLR and CIMT levels of Rtx patients were significantly increased compared to healthy subjects (p<0.0001, p=0.001, p<0.0001, respectively). sTWEAK was also found to be decreased when eGFR was decreased (p=0.04 between all groups). CIMT was positively correlated with sTWEAK and NLR in Rtx patients (r=0.81, p<0.0001 and r=0.33, p=0.006, respectively). sTWEAK was also positively correlated with NLR (r=0.37, p=0.002). In the multivariate analysis only sTWEAK was found to be an independent variable of increased CIMT. Conclusion: sTWEAK might have a role in the pathogenesis of ongoing atherosclerosis in Rtx patients.en_US
dc.description.sponsorshipERA-EDTA fellowship programen_US
dc.description.sponsorshipDr. A. Gaipov received grant support from the ERA-EDTA fellowship program.en_US
dc.identifier.doi10.1186/1471-2369-14-144
dc.identifier.issn1471-2369
dc.identifier.pmid23849432en_US
dc.identifier.scopus2-s2.0-84880288779en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/1471-2369-14-144
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14524
dc.identifier.volume14en_US
dc.identifier.wosWOS:000321783800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBiomed Central Ltden_US
dc.relation.ispartofBmc Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStweaken_US
dc.subjectNeutrophil-To-Lymphocyte Ratioen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectRenal Transplantationen_US
dc.titleSoluble TWEAK independently predicts atherosclerosis in renal transplant patientsen_US
dc.typeArticleen_US

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