Are bone morphogenetic protein-7 (BMP-7) serum levels correlated with development of hepatic fibrosis?

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dc.contributor.authorDemir, Nazlim Aktug
dc.contributor.authorKolgelier, Servet
dc.contributor.authorInkaya, Ahmet Cagkan
dc.contributor.authorSumer, Sua
dc.contributor.authorDemir, Lutfi Saltuk
dc.contributor.authorPehlivan, Fatma Seher
dc.contributor.authorArslan, Mahmure
dc.date.accessioned2024-02-23T14:35:26Z
dc.date.available2024-02-23T14:35:26Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Bone morphogenetic protein-7 (BMP-7) is a key protein in organogenesis and liver development. The protein has been studied in the context of liver fibrosis and regeneration. The aim of the present study was to explore any possible association between fibrosis levels (as revealed by liver biopsy) and serum BMP-7 levels. Methodology: A total of 189 patients with chronic hepatitis B and 51 healthy controls were enrolled in the study. Results: The study group contained 120 (63.5%) males and 69 (36.5%) females, and the control group contained 25 males (49.0%) and 26 females (51%). In general, serum BMP-7 values of patients were higher than those of controls (p = 0.001). Serum BMP-7 values of patients with liver fibrosis of stages 1, 2, 3, or 4 were higher than control values (all p values = 0.01), but the serum BMP-7 levels of patients with stage 5 fibrosis were similar to that of controls. Associations between fibrosis stage and the serum levels of BMP-7, ALT, HBVDNA, platelets, and albumin were all statistically significant (p = 0.001). The AUROC for the BMP-7 level in advanced stage fibrosis was found to be 0.23. The data were analyzed using the binary logistic regression analysis (backward stepwise method) and BMP-7, HBVDNA, and platelet levels were found to be risk factors associated with fibrosis (p values 0.031, 0.040, and 0.001, respectively). Conclusions: BMP-7 may play anti-inflammatory and anti-fibrogenic roles in the pathogenesis of chronic hepatitis B infection.en_US
dc.identifier.doi10.3855/jidc.4033
dc.identifier.endpage610en_US
dc.identifier.issn1972-2680
dc.identifier.issue5en_US
dc.identifier.pmid24820464en_US
dc.identifier.scopus2-s2.0-84900542901en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage605en_US
dc.identifier.urihttps://doi.org/10.3855/jidc.4033
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16025
dc.identifier.volume8en_US
dc.identifier.wosWOS:000339948900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJ Infection Developing Countriesen_US
dc.relation.ispartofJournal Of Infection In Developing Countriesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBmp-7en_US
dc.subjectChronic Hepatitis Ben_US
dc.subjectFibrosisen_US
dc.titleAre bone morphogenetic protein-7 (BMP-7) serum levels correlated with development of hepatic fibrosis?en_US
dc.typeArticleen_US

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