The relationship between red blood cell distribution width and myocardial ischemia in dobutamine stress echocardiography

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dc.contributor.authorAkilli, Hakan
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorAribas, Alpay
dc.contributor.authorAlibasic, Hajrudin
dc.contributor.authorYildirim, Oguzhan
dc.contributor.authorSertdemir, Ahmet Lutfi
dc.contributor.authorOzdemir, Kurtulus
dc.date.accessioned2024-02-23T14:21:13Z
dc.date.available2024-02-23T14:21:13Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjectivesAlthough elevated red blood cell distribution width (RDW) is associated with adverse outcomes in patients with cardiovascular disease, its role in demonstrating the presence and extent of myocardial ischemia for coronary artery disease is not known. The purpose of this study is to investigate the relationship between RDW and myocardial ischemia by using dobutamine stress echocardiography (DSE).MethodsA total of 917 patients were included in this prospective study. A complete blood analysis was performed for RDW before DSE. According to DSE results, patients were divided into two groups: DSE negative and DSE positive. According to the number of ischemic segments in DSE, patients were divided into three groups: no-ischemic segment, 1-3 ischemic segments, and 4 ischemic segments. In addition, coronary angiography results of DSE-positive groups were assessed in respect of RDW.ResultsThe RDW of the DSE-positive group (n=277) was higher than for the DSE-negative group (n=640) (13.51.5 vs. 12.7 +/- 1.3%, P<0.001, respectively). Elevated RDW values were also related to higher number of ischemic segments (no-ischemic segment group: 12.7 +/- 1.3, 1-3 ischemic segments group: 13.2 +/- 1.5, and 4 ischemic segments group: 14.2 +/- 1.3, P<0.001). A receiver operating curve analysis showed a cut-off value of RDW greater than 13.5% for predicting myocardial ischemia (sensitivity: 57.0%, specificity: 77.8%, positive predictive value: 52.7%, negative predictive value: 80.7%). In addition, positive predictive value of DSE was increased from 82.4 to 94.2% for detecting coronary artery disease by coronary angiography, when RDW (>13.5%) was used.ConclusionRDW is related to the presence and extent of myocardial ischemia in DSE. A high RDW increases the diagnostic accuracy of DSE.en_US
dc.identifier.doi10.1097/MCA.0000000000000068
dc.identifier.endpage158en_US
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue2en_US
dc.identifier.pmid24335414en_US
dc.identifier.scopus2-s2.0-84894090223en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage152en_US
dc.identifier.urihttps://doi.org/10.1097/MCA.0000000000000068
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13496
dc.identifier.volume25en_US
dc.identifier.wosWOS:000331216900012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDobutamine Stress Echocardiographyen_US
dc.subjectIschemiaen_US
dc.subjectRed Blood Cell Distribution Widthen_US
dc.titleThe relationship between red blood cell distribution width and myocardial ischemia in dobutamine stress echocardiographyen_US
dc.typeArticleen_US

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