Interchromosomal effect: Report of a father and son, bearing different translocations of the same chromosome, and a review of the current literature

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dc.contributor.authorYildirim, Mahmut Selman
dc.contributor.authorArslan, Ahmet Burak
dc.contributor.authorZamani, Ayse Gul
dc.date.accessioned2024-02-23T14:24:01Z
dc.date.available2024-02-23T14:24:01Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractInterchromosomal effect is a controversial phenomenon postulating that during gametogenesis of translocation carriers, aside from the unbalanced segregation of chromosomes involved in the translocation, other, structurally normal chromosomes might also be affected and segregated abnormally. Here, we present a balanced reciprocal translocation carrier t(15;20)(q11;p13), and his son, bearing a different translocation of chromosome 15, t(15;Y)(q11;q12). To further elucidate the so-far-controversial interchromosomal effect phenomenon, published original articles and case reports about interchromosomal effect were reviewed. The father was a carrier of t(15;20)(q11;p13). His wife's karyotype was normal. During a pregnancy occurred without any preceding procedure, amniocentesis was recommended to the family and performed. Result of the amniocentesis revealed a different translocation of chromosome 15; t(15;Y)(q11;q12). To our knowledge, this is the first report of two generations within a family, bearing different translocations of a chromosome. On top of all previous studies investigating ICE, our case adds an important finding, showing not only the rate of aneuploidies of structurally normal chromosomes, but also the rate of this 'alternating translocations' might be increased in translocation carriers, and this could be an important clue about interchromosomal effects.en_US
dc.identifier.doi10.1111/and.13805
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue1en_US
dc.identifier.pmid32862490en_US
dc.identifier.scopus2-s2.0-85089985408en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.13805
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13784
dc.identifier.volume53en_US
dc.identifier.wosWOS:000563756700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAneuploidyen_US
dc.subjectIceen_US
dc.subjectInfertilityen_US
dc.subjectInterchromosomal Effecten_US
dc.subjectTranslocationen_US
dc.titleInterchromosomal effect: Report of a father and son, bearing different translocations of the same chromosome, and a review of the current literatureen_US
dc.typeReview Articleen_US

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