The role of regulatory T cells in allergic rhinitis and their correlation with IL-10, IL-17 and neopterin levels in serum and nasal lavage fluid

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dc.contributor.authorErkan, Kadriye
dc.contributor.authorBozkurt, Mete K.
dc.contributor.authorArtac, Hasibe
dc.contributor.authorOzdemir, Hulya
dc.contributor.authorUnlu, Ali
dc.contributor.authorKorucu, Emine N.
dc.contributor.authorElsurer, Cagdas
dc.date.accessioned2024-02-23T13:43:48Z
dc.date.available2024-02-23T13:43:48Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractPurpose Allergic rhinitis (AR), is an IgE-mediated inflammation of the nose. Regulatory T cells (Tregs) and inflammatory cytokines have been shown to play a critical role in allergic airway inflammation. The aim of the study was to compare the levels of blood T lymphocyte subsets and IL-10, IL-17 and neopterin concentrations in serum and nasal lavage of patients with AR compared to healthy subjects. Methods The study included 38 subjects with moderate-severe AR and 36 sex- and age-matched controls. Peripheral blood CD3+, CD3+CD4+ and CD4+CD25+Foxp3 percentages were evaluated using flow cytometry. Levels of IL-10, IL-17 and neopterin were measured both in serum and nasal lavage fluid with ELISA and HPLC, respectively. Results No difference was found in the percentages of T lymphocyte subsets between the two groups (p > 0.05). Serum IL-10 levels were similar (p > 0.05), whereas nasal IL-10 was lower in AR subjects compared to control group (2.22 +/- 0.91 and 3.12 +/- 1.45 pg/ml, respectively) (p < 0.05). Mean serum and nasal IL-17 were higher in AR (107.7 +/- 79.61 and 527.36 +/- 738.7 pg/ml) than the control group (76.29 +/- 28.94 and 328.9 +/- 430.8 pg/ml) (p < 0.05 and p > 0.05). There were no significant differences in serum and nasal neopterin levels (p > 0.05). Conclusions Although there were no differences in the distribution of lymphocyte subsets between the AR and control groups, the finding of higher levels of serum and nasal IL-17 and lower levels of nasal IL-10 support the cytokine imbalance in the pathogenesis of AR.en_US
dc.identifier.doi10.1007/s00405-020-05811-4
dc.identifier.endpage1114en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue4en_US
dc.identifier.pmid31993765en_US
dc.identifier.scopus2-s2.0-85078720192en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1109en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-020-05811-4
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10932
dc.identifier.volume277en_US
dc.identifier.wosWOS:000515628000003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergic Rhinitisen_US
dc.subjectRegulatory T Cellsen_US
dc.subjectIl-10en_US
dc.subjectIl-17en_US
dc.subjectNeopterinen_US
dc.titleThe role of regulatory T cells in allergic rhinitis and their correlation with IL-10, IL-17 and neopterin levels in serum and nasal lavage fluiden_US
dc.typeArticleen_US

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