THE EFFECT OF ADIPOSE TISSUE STROMAL VASCULAR FRACTION COMBINED WITH PLATELET-RICH PLASMA ON IRRADIATION-INDUCED CAPSULAR CONTRACTURE AROUND SILICONE IMPLANTS

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dc.contributor.authorGundeslioglu, Ayse Ozlem
dc.contributor.authorInan, Irfan
dc.contributor.authorTezcan, Yilmaz
dc.contributor.authorToy, Hatice
dc.contributor.authorEmlik, Dilek
dc.contributor.authorAktan, Murad
dc.contributor.authorDuman, Selcuk
dc.date.accessioned2024-02-23T14:45:48Z
dc.date.available2024-02-23T14:45:48Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractThe exact reason and pathogenesis of capsule formation around breast implant after cosmetic and reconstructive breast enhancement is still unclear. However, recent studies and clinical observations regarding the application of adipose-derived mesenchymal stem cells around implanted biomaterials have shown encouraging results. In this study, the effects of the adipose-derived stromal vascular fraction combined with platelet-rich plasma on capsule formation around silicone implants were investigated in irradiated rats. After implantation of silicones implants bilaterally on the rat dorsal area, both sides were irradiated with 10-Gy as single fraction electron beam irradiation. Following radiation, the mixture of stromal vascular fraction and platelet-rich plasma was injected to right sides of the animals. Left sides were injected with same amount of saline as a control. On day 30, capsule around the implants was evaluated in regarding the capsular thickness by ultrasonography, histopathology and immunohistochemical examination. The results demonstrated that there is no statistically significant difference between the treated and non-treated groups in ultrasonographic, histopathologic, and immunohistochemical evaluations. These preliminary results demonstrated that adipose-derived stem cells with platelet rich plasma do not have efficiency for integration of tissue and silicone implants and to reduce capsule formation and further studies are requireden_US
dc.identifier.endpage12en_US
dc.identifier.issn2528-8644
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17634
dc.identifier.volume22en_US
dc.identifier.wosWOS:000416770600002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofTurkish Journal Of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStromal Vascular Fractionen_US
dc.subjectPlatelet Rich Plasmaen_US
dc.subjectCapsuleen_US
dc.subjectRadiationen_US
dc.titleTHE EFFECT OF ADIPOSE TISSUE STROMAL VASCULAR FRACTION COMBINED WITH PLATELET-RICH PLASMA ON IRRADIATION-INDUCED CAPSULAR CONTRACTURE AROUND SILICONE IMPLANTSen_US
dc.typeArticleen_US

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