Animal models of acute otitis media - A review with practical implications for laboratory research

Basit Öğe Kaydı
dc.contributor.authorDavidoss, N. H.
dc.contributor.authorVarsak, Y. K.
dc.contributor.authorMaria, P. L. Santa
dc.date.accessioned2024-02-23T14:02:06Z
dc.date.available2024-02-23T14:02:06Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractConsiderable animal research has focused on developing new strategies for the prevention and treatment of acute otitis media (AOM). Several experimental models of AOM have thus been developed. A PubMed search of the English literature was conducted from 1975 to July 2016 using the search terms animal model and otitis media from which 91 published studies were included for analysis, yielding 123 animal models. The rat, mouse and chinchilla are the preferred animals for experimental AOM models with their individual advantages and disadvantages. The most common pathogens used to create AOM are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. Streptococcus pneumoniae (types 3, 23 and 6A) and non-typeable Haemophilus influenzae (NTHi) are best options for inoculation into rat and mouse models. Adding viral pathogens such as RSV and Influenza A virus, along with creating ET dysfunction, are useful adjuncts in animal models of AOM. Antibiotic prophylaxis may interfere with the inflammatory response without a significant reduction in animal mortality. (C) 2018 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.anorl.2017.06.013
dc.identifier.endpage190en_US
dc.identifier.issn1879-7296
dc.identifier.issn1879-730X
dc.identifier.issue3en_US
dc.identifier.pmid29656888en_US
dc.identifier.scopus2-s2.0-85045277617en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://doi.org/10.1016/j.anorl.2017.06.013
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11584
dc.identifier.volume135en_US
dc.identifier.wosWOS:000433338700009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Masson, Corporation Officeen_US
dc.relation.ispartofEuropean Annals Of Otorhinolaryngology-Head And Neck Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMiddle Earen_US
dc.subjectAnimal Modelen_US
dc.subjectOtitis Mediaen_US
dc.titleAnimal models of acute otitis media - A review with practical implications for laboratory researchen_US
dc.typeReview Articleen_US

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