Evaluation of Contact Lens-Induced Changes in Keratoconic Corneas Using In Vivo Confocal Microscopy

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dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorOzkagnici, Ahmet
dc.contributor.authorMalik, Rayaz A.
dc.contributor.authorOltulu, Refik
dc.date.accessioned2024-02-23T14:26:47Z
dc.date.available2024-02-23T14:26:47Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractPURPOSE. To quantitatively analyze laser scanning in vivo confocal microscopy (IVCM) images of all corneal layers in contact lens-wearing and noncontact lens-wearing keratoconus patients. METHODS. The study population included rigid gas permeable (RGP) contact lens-wearing keratoconus patients (group 1; N = 29), keratoconus patients who did not wear contact lenses (group 2; N = 30), and subjects who neither had keratoconus nor wore contact lenses (group 3; N = 30), with groups 2 and 3 matched to group 1 by age and sex. The central cornea was examined with IVCM in all subjects. The mean duration of contact lens wear was 5.50 +/- 3.68 years (range, 2-15 years). RESULTS. Eyes with keratoconus showed significantly lower basal epithelial cell and anterior and posterior stromal keratocyte densities, as well as subbasal nerve fiber density, nerve branch density, and nerve fiber length compared with healthy control subjects. Furthermore, compared with group 2, group 1 had significantly lower basal epithelial cell density (4920 +/- 476 cells/mm(2) vs. 4503 +/- 461 cells/mm(2), P = 0.001) and anterior stromal keratocyte density (561 6 91 cells/mm2 vs. 464 6 55 cells/mm2, P < 0.001), but there was no significant difference for posterior stromal keratocyte density (P = 0.808), endothelial cell density (P = 0.699), or subbasal nerve fiber density (P = 0.142), nerve branch density (P = 0.614), and nerve fiber length (P = 0.850). CONCLUSIONS. Significant corneal microstructural abnormalities were observed in eyes with keratoconus. RGP contact lens wear was associated with a further reduction in the basal epithelial cell and anterior stromal keratocyte densities, but with no effect on posterior stromal keratocyte density, endothelial cell density, or corneal nerve morphology.en_US
dc.identifier.doi10.1167/iovs.13-12437
dc.identifier.endpage5391en_US
dc.identifier.issn0146-0404
dc.identifier.issn1552-5783
dc.identifier.issue8en_US
dc.identifier.pmid23882688en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage5385en_US
dc.identifier.urihttps://doi.org/10.1167/iovs.13-12437
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14335
dc.identifier.volume54en_US
dc.identifier.wosWOS:000325167200031en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Research Vision Ophthalmology Incen_US
dc.relation.ispartofInvestigative Ophthalmology & Visual Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKeratoconusen_US
dc.subjectConfocal Microscopyen_US
dc.subjectContact Lensen_US
dc.subjectCorneaen_US
dc.titleEvaluation of Contact Lens-Induced Changes in Keratoconic Corneas Using In Vivo Confocal Microscopyen_US
dc.typeArticleen_US

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