Association of an Endothelial Nitric Oxide Synthase Gene Polymorphism with Diabetic Retinopathy

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dc.contributor.authorInan, Sibel
dc.contributor.authorZengin, Nazmi
dc.contributor.authorOzturk, Banu Turgut
dc.contributor.authorKerimoglu, Hurkan
dc.contributor.authorUnlu, Ali
dc.contributor.authorDogan, Ismet
dc.date.accessioned2024-02-23T14:34:42Z
dc.date.available2024-02-23T14:34:42Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractThe association of the endothelial nitric oxide synthase (eNOS) G894T gene polymorphism with the severity of diabetic retinopathy (DRP) and macular edema (DME) was investigated. One hundred-seven patients with type-2 diabetes mellitus were included. Forty-five patients served as a control group. eNOS G894T gene polymorphism was analysed by polymerase chain reaction. The mean age was 55.8 +/- 9.4 years in the study group and 51.8 +/- 9.7 years in the control group. There was no significant difference in the genotypes between the diabetic and the control group, or between the non-DRP group and the DRP group. The frequency of the G allele was higher in the proliferative DRP group than that in the non-proliferative DRP group. The GG genotype of G894T gene polymorphism was associated with macular edema and hyperglycaemia. The eNOS G894T gene polymorphism seems to be associated with the DME and unregulated hyperglycaemia.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Project Committee [06102033]en_US
dc.description.sponsorshipThis work was supported by Necmettin Erbakan University Scientific Research Project Committee grant No: 06102033. The researchers thank Dr. Gulsum Yilmaz for her valuable assistance in laboratory work.en_US
dc.identifier.doi10.31901/24566330.2018/18.4.677
dc.identifier.endpage281en_US
dc.identifier.issn0972-3757
dc.identifier.issue4en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://doi.org/10.31901/24566330.2018/18.4.677
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15720
dc.identifier.volume18en_US
dc.identifier.wosWOS:000456090800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKamla-Raj Enterprisesen_US
dc.relation.ispartofInternational Journal Of Human Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGenotypeen_US
dc.subjectHyperglycaemiaen_US
dc.subjectMacularen_US
dc.subjectEdemaen_US
dc.subjectSeverityen_US
dc.titleAssociation of an Endothelial Nitric Oxide Synthase Gene Polymorphism with Diabetic Retinopathyen_US
dc.typeArticleen_US

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