Effect of sex steroids on soleus muscle response in hypocalcemic medium (in vitro)

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dc.contributor.authorKokcam, S. Said
dc.contributor.authorTekin, Sakir
dc.contributor.authorKartal, Adil
dc.contributor.authorAyaz, Murat
dc.contributor.authorSahin, Mustafa
dc.contributor.authorAcar, Fahreddin
dc.contributor.authorCakir, Murat
dc.date.accessioned2024-02-23T14:13:03Z
dc.date.available2024-02-23T14:13:03Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractPurpose: Postoperative hypocalcemia is a frequently encountered complication of thyroid surgery. Since hypocalcemic symptoms are closely associated with sex, the aim of this study is to investigate the effects of sex steroids on muscle tissue under hypocalcemic conditions. Methods: Six groups consisting of control male (M), control female (F), gonadectomized male (M -), gonadectomized female (F-), estradiol- applied gonadectomized male (MX), and testosterone- applied gonadectomized female (FX) rats were used. Contraction recordings were obtained from soleus muscle flaps. Maximal tension (PT), frequency required for 50% of PT (F50), contraction velocity at F50 (V50), and changes in contraction values (d[PT], d[F50], d[V50]) between normocalcemic and hypocalcemic conditions were calculated. Results: d[PT], d[F50], and d[V50] were significantly higher in M - and MX groups compared with control M group. Whereas d[PT], d[F50], and d[V50] parameters of the F- group were significantly higher than control F group, d[F50] and d[PT] of the FX group showed no significant change and d[V50] for the FX group was significantly lower. A comparison of control groups showed that d[PT], d[F50], and d[V50] of the F group were significantly higher than those of the M group. Conclusion: Whereas absence of both testosterone and estradiol caused an increase in hypocalcemia- induced changes in contraction parameters of rat skeletal muscle, presence or application of testosterone clearly stabilized contraction parameters. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects (BAP) [09102009]en_US
dc.description.sponsorshipThis study was supported by Selcuk University Scientific Research Projects (BAP) Grant 09102009 and experiments were carried out in the Selcuk University Biophysiscs Research Laboratory.en_US
dc.identifier.doi10.1016/j.jss.2013.02.029
dc.identifier.endpage888en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid23510550en_US
dc.identifier.scopus2-s2.0-84891682118en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage883en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2013.02.029
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12280
dc.identifier.volume185en_US
dc.identifier.wosWOS:000326938500079en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal Of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenderen_US
dc.subjectEstradiolen_US
dc.subjectTestosteroneen_US
dc.subjectSkeletal Muscleen_US
dc.subjectSoleusen_US
dc.subjectHypocalcemiaen_US
dc.titleEffect of sex steroids on soleus muscle response in hypocalcemic medium (in vitro)en_US
dc.typeArticleen_US

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