A novel marker relationship between carotid intima-media thickness and disease activity score-28 in patients with rheumatoid arthritis: human endothelial cell-specific molecule-1

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dc.contributor.authorTuzcu, Goksel
dc.contributor.authorUslu, Ali Ugur
dc.contributor.authorTuzcu, Ayca
dc.contributor.authorBaykara, Rabia Aydogan
dc.contributor.authorOmma, Ahmet
dc.contributor.authorKucuk, Adem
dc.date.accessioned2024-02-23T14:37:23Z
dc.date.available2024-02-23T14:37:23Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: Human endothelial cell-specific molecule-1 (endocan) is a marker of vascular endothelial dysfunction that may be used in the evaluation of inflammatory-associated atherosclerotic lesions. Endocan may be a marker for the evaluation of atherosclerosis and disease activity in rheumatoid arthritis (RA) patients. Materials and methods: We included 39 RA patients assessed according to the American College of Rheumatology/European League Against Rheumatology 2010 diagnostic criteria and recruited 30 age- and sex-matching healthy subjects for the control group. Results: Endocan values were 14.11 +/- 3.27 for the RA patients and 12.10 +/- 2.92 for the controls. The endocan values of the patients were significantly higher than those of the control group (P = 0.009). In the correlation analysis, endocan showed a significantly positive correlation with disease activity score-28 (r = 0.386, P = 0.029) and carotid intima-media thickness (cIMT) (r = 0.419, P = 0.008). Linear regression analysis revealed that there was an independent relationship between endocan and cIMT (P = 0.029). Conclusion: Endocan can be a marker for early atherosclerosis and disease activity in RA patients.en_US
dc.identifier.doi10.3906/sag-1806-60
dc.identifier.endpage1605en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid31655533en_US
dc.identifier.scopus2-s2.0-85076874589en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1599en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1806-60
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16081
dc.identifier.volume49en_US
dc.identifier.wosWOS:000504051300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHuman Endothelial Cell-Specific Molecule-1en_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectAtherosclerosisen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectMarkeren_US
dc.titleA novel marker relationship between carotid intima-media thickness and disease activity score-28 in patients with rheumatoid arthritis: human endothelial cell-specific molecule-1en_US
dc.typeArticleen_US

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