Effects of grape seed extract on oxidative stress and antioxidant defense markers in streptozotocin-induced diabetic rats

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dc.contributor.authorBelviranli, Muaz
dc.contributor.authorGokbel, Hakki
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorBuyukbas, Sadik
dc.date.accessioned2024-02-23T14:37:21Z
dc.date.available2024-02-23T14:37:21Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: To evaluate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant markers in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Thirty-six male rats were divided into the following four groups: control, GSE-supplemented control, diabetic, and GSE-supplemented diabetic. Beginning on day 7 after STZ injection, the rats were administered GSE (100 mg kg(-1) day(-1)) in drinking water for 6 weeks. At the end of week 6, rats were sacrificed by cardiac puncture. Plasma nitric oxide (NO) levels and xanthine oxidase (XO), adenosine deaminase (ADA), and glutathione peroxidase (GPx) activities were analyzed. Results: Both XO and ADA activities increased and NO levels decreased in diabetic rats (P < 0.05). GSE supplementation normalized all of these changes. Antioxidant enzyme activities decreased in diabetic rats compared to the controls (P < 0.05). GSE supplementation increased antioxidant enzyme activities in both diabetic and healthy rats (P < 0.05). Conclusion: These findings suggest that 6 weeks of oral GSE supplementation may prevent oxidative stress and improve antioxidant status in diabetic rats.en_US
dc.identifier.doi10.3906/sag-1404-5
dc.identifier.endpage495en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid26281311en_US
dc.identifier.scopus2-s2.0-84929725029en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage489en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1404-5
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16069
dc.identifier.volume45en_US
dc.identifier.wosWOS:000356357800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExperimental Diabetesen_US
dc.subjectGrape Seed Extracten_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidant Enzyme Activityen_US
dc.subjectAdenosine Deaminaseen_US
dc.subjectNitric Oxideen_US
dc.titleEffects of grape seed extract on oxidative stress and antioxidant defense markers in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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