Boric acid inhibits alveolar bone loss in rats by affecting RANKL and osteoprotegerin expression

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dc.contributor.authorSaglam, M.
dc.contributor.authorHatipoglu, M.
dc.contributor.authorKoseoglu, S.
dc.contributor.authorEsen, H. H.
dc.contributor.authorKelebek, S.
dc.date.accessioned2024-02-23T14:24:31Z
dc.date.available2024-02-23T14:24:31Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBackground and Objective: The goal of the present study was to evaluate the effects of systemic boric acid on the levels of expression of RANKL and osteoprotegerin (OPG) and on histopathologic and histometric changes in a rat periodontitis model. Material and Methods: Twenty-four Wistar rats were divided into three groups of eight animals each: nonligated (NL); ligature only (LO); and ligature plus treatment with boric acid (BA) (3 mg/kg per day for 11 d). A 4/0 silk suture was placed in a subgingival position around the mandibular right first molars; after 11 d the rats were killed, and alveolar bone loss in the first molars was histometrically determined. Periodontal tissues were examined histopathologically to assess the differences among the study groups. RANKL and OPG were detected immunohistochemically. Results: Alveolar bone loss was significantly higher in the LO group than in the BA and NL groups (p < 0.05). The number of inflammatory infiltrate and osteoclasts in the LO group was significantly higher than that in the NL and BA groups (p < 0.05). The numbers of osteoblasts in LO and BA groups were significantly higher compared with NL group (p < 0.05). There were significantly more RANKL-positive cells in the LO group than in the BA and NL groups (p < 0.05). There was a higher number of OPG-positive cells in the BA group than in the LO and NL groups (p < 0.05). Conclusion: The present study shows that systemic administration of boric acid may reduce alveolar bone loss by affecting the RANKL/OPG balance in periodontal disease in rats.en_US
dc.identifier.doi10.1111/jre.12126
dc.identifier.endpage479en_US
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue4en_US
dc.identifier.pmid24033134en_US
dc.identifier.scopus2-s2.0-84904061124en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage472en_US
dc.identifier.urihttps://doi.org/10.1111/jre.12126
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13988
dc.identifier.volume49en_US
dc.identifier.wosWOS:000339503800007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlveolar Bone Lossen_US
dc.subjectBoric Aciden_US
dc.subjectOsteoprotegerinen_US
dc.subjectPeriodontal Diseasesen_US
dc.subjectReceptor Activator Of Nuclear Factor-Kappa B Liganden_US
dc.titleBoric acid inhibits alveolar bone loss in rats by affecting RANKL and osteoprotegerin expressionen_US
dc.typeArticleen_US

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