The effect of progesterone on systemic inflammation and oxidative stress in the rat model of sepsis

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dc.contributor.authorAksoy, Ayse Nur
dc.contributor.authorToker, Aysun
dc.contributor.authorCelik, Muhammet
dc.contributor.authorAksoy, Mehmet
dc.contributor.authorHalici, Zekai
dc.contributor.authorAksoy, Hulya
dc.date.accessioned2024-02-23T14:37:42Z
dc.date.available2024-02-23T14:37:42Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjectives: To explore the protective effect of progesterone on inflammation and oxidative stress in a rat model of sepsis created by cecal ligation and puncture (CLP). Materials and Methods: Rats were randomly divided into 4 groups: Overiectomy group (OVX), sham operated (control), sepsis (CLP) group and progesterone-treated CLP group (CLP+ progesterone). The rats in CLP+ progesterone group received intraperitoneal progesterone (2 mg/kg). Cardiac blood samples were obtained for the measurement levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Tissue samples, including liver, kidney and uterus of rats were prepared to determine activities of myeloperoxidase (MPO), glutathione peroxidase (GPx) and levels of malondialdehyde (MDA). Results: Increased serum IL-6 and TNF-alpha levels were found in the CLP group in comparison with the control group (P = 0.01, P = 0.02; respectively). In CLP+ progesterone group, mean MDA concentration of kidney tissue was significantly lower than in CLP group (P = 0.003). Liver MDA concentration of the CLP+ progesterone group was not significantly different from that of the control group. While there were no significant differences among groups regarding liver MPO; in the CLP group, MPO activity in kidney (P = 0.02) and uterine tissues (P = 0.03) were found to be significantly higher compared to the control group. In CLP+ progesterone group, mean MPO activities of all tissues were not different than those of control group. The uterine tissue GPx activity in the CLP+ progesterone group was not statistically significantly different from control group. Conclusions: We suggest that progesterone ameliorates sepsis syndrome by reduction of the inflammatory cytokines IL-6 and TNF-alpha, and by restoration of antioxidant enzyme activities in some tissues.en_US
dc.identifier.doi10.4103/0253-7613.144922
dc.identifier.endpage626en_US
dc.identifier.issn0253-7613
dc.identifier.issn1998-3751
dc.identifier.issue6en_US
dc.identifier.pmid25538334en_US
dc.identifier.scopus2-s2.0-84916197232en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage622en_US
dc.identifier.urihttps://doi.org/10.4103/0253-7613.144922
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16208
dc.identifier.volume46en_US
dc.identifier.wosWOS:000348432400011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofIndian Journal Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectOxidative Stressen_US
dc.subjectProgesteroneen_US
dc.subjectSepsisen_US
dc.titleThe effect of progesterone on systemic inflammation and oxidative stress in the rat model of sepsisen_US
dc.typeArticleen_US

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