Impact of the HEAD-US Scoring System for Observing the Protective Effect of Prophylaxis in Hemophilia Patients: A Prospective, Multicenter, Observational Study

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dc.contributor.authorKavakli, Kaan
dc.contributor.authorOzbek, Suha Sureyya
dc.contributor.authorAntmen, Ali Bulent
dc.contributor.authorSahin, Fahri
dc.contributor.authorAytac, Sevkiye Selin
dc.contributor.authorKupesiz, Alphan
dc.contributor.authorZulfikar, Bulent
dc.date.accessioned2024-02-23T14:38:16Z
dc.date.available2024-02-23T14:38:16Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective: This study aimed to observe the preventive effect of prophylactic treatment on joint health in people with hemophilia (PwH) and to investigate the importance of integration of ultrasonographic examination into clinical and radiological evaluation of the joints. Materials and Methods: This national, multicenter, prospective, observational study included male patients aged >= 6 years with the diagnosis of moderate or severe hemophilia A or B from 8 centers across Turkey between January 2017 and March 2019. Patients were followed for 1 year with 5 visits (baseline and 3rd, 6th, 9th, and 12th month visits). The Hemophilia Joint Health Score (HJHS) was used for physical examination of joints, the Pettersson scoring system was used for radiological assessment, point-of-care (POC) ultrasonography was used for bilateral examinations of joints, and the Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score was used for evaluation of ultrasonography results. Results: Seventy-three PwH, of whom 62 had hemophilia A and 11 had hemophilia B, were included and 24.7% had target joints at baseline. The HJHS and HEAD-US scores were significantly increased at the 12th month in all patients. These scores were also higher in the hemophilia A subgroup than the hemophilia B subgroup. However, in the childhood group, the increment of scores was not significant. The HEAD-US total score was significantly correlated with both the HJHS total score and Pettersson total score at baseline and at the 12th month. Conclusion: The HEAD-US and HJHS scoring systems are valuable tools during follow-up examinations of PwH and they complement each other. We suggest that POC ultrasonographic evaluation and the HEAD-US scoring system may be integrated into differential diagnosis of bleeding and long-term monitoring for joint health as a routine procedure.en_US
dc.identifier.doi10.4274/tjh.galenos.2021.2020.0717
dc.identifier.endpage110en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue2en_US
dc.identifier.pmid33508912en_US
dc.identifier.scopus2-s2.0-85107711215en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2021.2020.0717
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16448
dc.identifier.volume38en_US
dc.identifier.wosWOS:000658294800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal Of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHemophilic Arthropathyen_US
dc.subjectJoint Scoresen_US
dc.subjectHjhsen_US
dc.subjectUltrasonographyen_US
dc.titleImpact of the HEAD-US Scoring System for Observing the Protective Effect of Prophylaxis in Hemophilia Patients: A Prospective, Multicenter, Observational Studyen_US
dc.typeArticleen_US

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