The effect of isotretinoin therapy on oxidative damage in rats

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dc.contributor.authorDaye, Munise
dc.contributor.authorBelviranli, Muaz
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorMevlitoglu, Inci
dc.contributor.authorOz, Mehmet
dc.date.accessioned2024-02-23T14:24:06Z
dc.date.available2024-02-23T14:24:06Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractIsotretinoin is prescribed in many dermatologic disorders, but mostly in acne. There is limited research about oxidative stress induced by isotretinoin and its effects on the liver tissue, muscle tissue, and blood. In this study, oxidative damage of isotretinoin on the liver, muscles, and blood in rats at the therapeutic dosage for humans, is evaluated. Thirty, 2-months-old Wistar albino rats were randomly divided into four groups. Isotretinoin was administered at the human equivalent low dose of 7.5 mg/kg by gavage. Blood, liver, and skeletal muscle samples were taken from the animals under anesthesia. Oxidative stress and antioxidant defense markers such as Malondialdehyde (MDA), Protein carbonyl (PC), 8-OHDG (8-hydroxy-deoxyguanosine), SOD (Superoxide dismutase), GSH(Glutathione), GPX (glutathione peroxidase), NO (Nitric Oxide) levels, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), and creatine kinase (CK) levels were measured. There were significant differences between the ALT values of the control group and the third month of isotretinoin treatment group. Oxidative stress markers such as 8-OHDG, PC, GSH, GPX, and NO values significantly differed in month 3. SOD was significantly lower in the treatment groups compared to the control group. Our study supports that the levels of oxidative markers are increasing with the isotretinoin treatment so this may flare acne. GPX levels increased at the muscle tissue level, and may be responsible for the myopathy that is seen in acne patients. Addition of antioxidants to isotretinoin treatment may be beneficial in reducing oxidative damage.en_US
dc.description.sponsorshipScientific Research Projects Department of Necmettin Erbakan University [121218008]en_US
dc.description.sponsorshipThis study supported and funded by Scientific Research Projects Department of Necmettin Erbakan University (Project no: 121218008).en_US
dc.identifier.doi10.1111/dth.14111
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue6en_US
dc.identifier.pmid32737933en_US
dc.identifier.scopus2-s2.0-85089858415en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/dth.14111
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13820
dc.identifier.volume33en_US
dc.identifier.wosWOS:000562476400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDermatologic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlooden_US
dc.subjectIsotretinoinen_US
dc.subjectLiveren_US
dc.subjectMuscleen_US
dc.subjectOxidative Stressen_US
dc.subjectRaten_US
dc.titleThe effect of isotretinoin therapy on oxidative damage in ratsen_US
dc.typeArticleen_US

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