Evaluation of oxidant/anti-oxidants status in patients with mild acute pancreatitis

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dc.contributor.authorBaser, Husniye
dc.contributor.authorCan, Ummugulsum
dc.contributor.authorKarasoy, Deniz
dc.contributor.authorAy, Abdulhalim Serden
dc.contributor.authorBaser, Salih
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorEcirli, Samil
dc.date.accessioned2024-02-23T14:48:53Z
dc.date.available2024-02-23T14:48:53Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBackground and aim : Acute pancreatitis (AP), an inflammatory disorder of the pancreas, is associated with significant morbidity and mortality. The pathogenesis of AP has been suggested to involve high oxidative stress (OS), combined with inadequate antioxidant status. We aimed to investigate the levels of serum total anti-oxidant status (TAS), total oxidant status (TOS) and ischemia-modified albumin (IMA) in patients with mild AP. Methods : Thirty subjects with mild AP and 29 healthy controls were enrolled into the study. The levels of TAS, TOS and IMA, Creactive protein (CRP), high sensitivity CRP (hs-CRP) and fibrinogen were measured in both groups. Results : TAS levels were significantly lower (p = 0.037), while IMA levels were significantly higher (p < 0.001) in patients, compared to controls. TOS levels were similar between two groups. Fibrinogen, CRP and hs-CRP levels were significantly higher in patients than those of controls (p < 0.001 for all parameters). IMA levels were positively correlated with amylase and lipase levels (r = 0.448, p = 0.001 and r = 0.469, p < 0.001, respectively). There was a negative correlation between TAS levels, and amylase and lipase levels (r = -0.277, p = 0.035 and r = -0.278, p = 0.034, respectively). Conclusions : OS is reported to be associated with the inflammatory process and the severity of AP. In our study, among OS parameters, an increase in IMA levels and a decrease in TAS levels were observed in mild AP patients.en_US
dc.identifier.endpage28en_US
dc.identifier.issn1784-3227
dc.identifier.issue1en_US
dc.identifier.pmid26852760en_US
dc.identifier.scopus2-s2.0-84957991498en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17866
dc.identifier.volume79en_US
dc.identifier.wosWOS:000373453800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Catholique Louvain-Uclen_US
dc.relation.ispartofActa Gastro-Enterologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPancreatitisen_US
dc.subjectOxidative Stressen_US
dc.subjectTotal Anti-Oxidant Statusen_US
dc.subjectTotal Oxidant Statusen_US
dc.subjectIschemia-Modified Albuminen_US
dc.titleEvaluation of oxidant/anti-oxidants status in patients with mild acute pancreatitisen_US
dc.typeArticleen_US

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